TY - JOUR
AB - Abstract The Food and Drug Administration (FDA) has recommended that all donated blood be screened for antibodies to human immunodeficiency virus type 2 (HIV-2) beginning no later than June 1, 1992. This article provides Center for Disease Control (CDC) recommendations for the diagnosis of HIV-1 and HIV-2 infections in persons being tested in settings other than blood centers and CDC/FDA guidelines for serologic testing with combination HIV-l/HIV-2 screening enzyme immunoassays (EIAs). Epidemiologic data indicate that the prevalence of HIV-2 infections in persons in the United States is extremely low. Therefore, CDC does not recommend routine testing for HIV-2 in settings other than blood centers. However, when HIV testing is indicated, tests for antibodies to both HIV-1 and HIV-2 should be obtained if epidemiologic risk factors for HIV-infection are present, if clinical evidence exists for HIV disease in the absence of a positive test for antibodies to HIV-1, or if HIV-1 Western blot results exhibit the unusual indeterminate pattern of gag plus pol bands in the absence of env bands. The following procedures are recommended if testing for both HIV-1 and HIV-2 is performed by means of a combination HIV-l/HIV-2 EIA. A repeatedly reactive specimen by HIVl/HIV-2 EIA should be tested by HIV-1 Western blot (or another licensed HIV-1 supplemental test). A positive result by HIV-1 Western blot confirms the presence of antibodies to HIV, and testing for HIV-2 is recommended only if HIV-2 risk factors are present. If the HIV-1 Western blot result is negative or indeterminate, an HIV-2 EIA should be performed. If the HIV-2 EIA is positive, an HIV-2 supplemental test should be performed. This content is only available as a PDF. © American Society of Clinical Pathologists
TI - Testing for Antibodies to HIV Type 2 in the United States: Centers for Disease Control
JO - Laboratory Medicine
DO - 10.1093/labmed/23.12.819
DA - 1992-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/testing-for-antibodies-to-hiv-type-2-in-the-united-states-centers-for-fY98JnqBh7
SP - 819
EP - 823
VL - 23
IS - 12
DP - DeepDyve
ER -