TY - JOUR
AU - Stratigos, J.
AB - British Journal of Dermatology (1987) 117, 797-800. Correspondence The role of sweat in the pharmacokinettcs of ketoconazole and griseofulvin MADAM, Griseofulvin'"* and ketoconazole^*' have been previously shown to be quickly transfered by sweattothesurfaceofhealthy skin. This effect in normal skinisconsideredby the above authors to be very important in treatment with both griseofulvin and ketoconazole. In our previous studies in dematophytoses,' cutaneous candidiasis^ and pityriasis versicolor** we have observed the existence of severe hypohidrosis which was restored to normal after treatment (Figs i and 2). This hypohidrosis was found to be caused mainly by sweat duct occlusion. Sweating was studied using the iodine-starch-silicone plastic impression method.^ Based on our observations of sweat gland disturbances in affected skin we suggest that neither griseofulvin nor ketoconazole reaches fungal skin infections directly via sweat. We cannot exclude the possibility of indirect transfer of these drugs to fungal lesions by sweat from, for instance, adjacent normal skin, and contact with apposing skin surfaces and clothes. The contribution of these drugs reaching the site of infection indirectly could not estimated accurately. Griseofulvin and ketoconazole might well protect the normal skin surface from the spread of infection, and during the summer months excretion in sweat might be 
TI - The role of sweat in the pharmacokinetics of ketoconazole and griseofulvin
JF - British Journal of Dermatology
DO - 10.1111/j.1365-2133.1987.tb07362.x
DA - 1987-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-role-of-sweat-in-the-pharmacokinetics-of-ketoconazole-and-fO0aZeq0fq
SP - 797
EP - 798
VL - 117
IS - 6
DP - DeepDyve
ER -