TY - JOUR
AU1 - Michalek, Suzanne M.
AU2 - Moore, Robert N.
AU3 - McGhee, Jerry R.
AU4 - Rosenstreich, David L.
AU5 - Mergenhagen, Stephan E.
AB - Mice that are unresponsive to lipopolysaccharide (LPS) (strain C3H/HeJ) can be rendered LPS-sensitive by the adoptive transfer of bone marrow cells from LPSsensitive mice (strain C3H/HeN). This model of adoptive transfer was used to evaluate the contribution of lymphoreticular cells to five effects of endotoxin on the host: immunogenicity, adjuvanticity, lethality, induction of interferon, and induction of colony-stimulating factor. C3H/HeJ mice became sensitive to each of these effects after adoptive transfer of bone marrow cells from C3H/HeN mice. The efficacy of transfer was directly proportional to the dose of X-irradiation and inversely proportional to the number of surviving host stem cells. The most effective dose of radiation was 850 rad, and C3H/HeN→C3H/HeJx chimeras prepared at this dose were as sensitive to LPS for each parameter tested as were the C3H/HeN donors except for a threefold greater resistance to lethality than LPS-responsive C3H/HeN mice. C3H/HeN mice could also be rendered unresponsive to LPS by the adoptive transfer of C3H/HeJ bone marrow cells. C3H/HeN chimeras were resistant to all of the effects of LPS studied except for the induction of colony-stimulating factor. These results demonstrate that lymphocytes and/or macrophages playa primary role in mediating a number of diverse and seemingly unrelated host responses to endotoxin.
TI - The Primary Role of Lymphoreticnlar Cells in the Mediation of Host Responses to Bacterial Endotoxim
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/141.1.55
DA - 1980-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-primary-role-of-lymphoreticnlar-cells-in-the-mediation-of-host-fK30VLLrog
SP - 55
EP - 63
VL - 141
IS - 1
DP - DeepDyve
ER -