TY - JOUR
AU - Suzuki, Yasuhiko
AB - BackgroundTuberculosis (TB) remains an important infectious disease and different genotypes have been reported. This study aimed to investigate the genetic diversity and molecular epidemiology of TB in the lower northern region of Thailand, where genotyping data are limited.MethodsA total of 159 Mycobacterium tuberculosis complex (MTBC) isolates from this region were genotyped by spoligotyping and the major spoligotypes were further subdivided by the mycobacterial interspersed repetitive unit–variable number tandem repeat (MIRU-VNTR) method.ResultsSpoligotyping identified 34 types and classified them into 14 clusters. East African–Indian (EAI) groups were the most frequent (44.7%), followed by Beijing (36.5%), with a higher prevalence of drug resistance. By 15-loci MIRU-VNTR typing, the major groups of the Beijing and EAI2_NTB were further differentiated into 44 and 21 subtypes forming 9 and 5 subclusters with cluster rates of 0.26 and 0.44, respectively. The Hunter–Gaston Discriminatory Index among the Beijing and EAI2_NTB groups were 0.987 and 0.931, respectively, indicating high diversity.ConclusionsThis is the first look at the MTBC genotypes in the lower northern region of Thailand, which could aid in understanding the distribution and potential spread of MTBC and Mycobacterium bovis in the target region to support TB control in Thailand.
TI - The first insight into Mycobacterium tuberculosis complex isolates in the lower northern region in Thailand
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
DO - 10.1093/trstmh/trae014
DA - 2024-03-30
UR - https://www.deepdyve.com/lp/oxford-university-press/the-first-insight-into-mycobacterium-tuberculosis-complex-isolates-in-fIJ6bePUw2
SP - 527
EP - 536
VL - 118
IS - 8
DP - DeepDyve
ER -