TY - JOUR
AU1 - Lee, Jason
AU2 - Choi, Seo
AU3 - Im, Jung
AU4 - Seong, Jinsil
AB - Purpose Reirradiation has the potential to provide effective local control of upper abdominal malignancies. This study aimed to evaluate the safety and efficacy of reirradiation for upper abdominal malignancies. Methods A total of 42 patients with a history of prior radiotherapy (RT) received reirradiation for abdominal malignancies between 2005 and 2017. Each patient’s medical records, contours, and dose distribution for both RT courses were reviewed. The median dose of the prior RT was 50.0 Gy (range, 30.0–60.0 Gy) and the median dose of reirradiation was 45.0 Gy (range, 15.0–75.0 Gy). Results With a median follow-up of 10.9 months, the median infield-failure-free survival (IFFS) rate was 9.2 months. Gross tumor volume (GTV) significantly related to IFFS in both the univariate (p = 0.009) and multivariate analyses (p = 0.024), and patients with a GTV of <60.0 mL had an improved IFFS (p = 0.001). Four patients experienced ≥grade 3 late toxicities. In the retrospective dose reconstruction analysis in these patients, the cumulative dose to the most exposed 2 cc (D2cc) of the duodenum was >60.0 Gy (range, 60.1–73.7 Gy). In the univariate analysis, the D2cc of the duodenum and a preexisting duodenal ulcer identified using endoscopy prior to reirradiation significantly 
TI - Clinical safety and efficacy of salvage reirradiation for upper abdominal malignancies
JF - Strahlentherapie und Onkologie
DO - 10.1007/s00066-018-01420-7
DA - 2019-01-28
UR - https://www.deepdyve.com/lp/springer-journals/clinical-safety-and-efficacy-of-salvage-reirradiation-for-upper-fBc6qI2OPQ
SP - 526
EP - 533
VL - 195
IS - 6
DP - DeepDyve
ER -