TY - JOUR
AB - ABSTR AC TS FROM THE CHINESE JOURNAL OF HYPERTENSION Cardiovascular Effects of Hydrogen Sulfide in the Caudal Ventrolateral Medulla Are Mediated by ATP-Sensitive Potassium Channels and Glutamate Receptors 1 1 1 1 1 1 Yan Lu, Bin Li, Hong-yan Cai, Dong-sheng Cheng, De-hong Li, and Hao Li Clinical Laboratory Department, First Hospital of Chinese People’s Liberation Army, Lanzhou, Gansu, China. Correspondence: Yan Lu (lu73free@gmail.com). Objective: Our aim was to investigate the effects and mechanisms of hydrogen sulfide (H S), injected within the caudal ventrolateral medulla (CVLM), on blood pressure (BP) and heart rate (HR) in anesthetized rats. Methods: Sixty-seven male Sprague-Dawley (SD) rats were randomized into H S treatment (n  =  34) or antagonist pretreatment (n  =  33) groups. The H S treatment group was further divided into the following subgroups: control (artificial cerebrospinal fluid [aCSF]) 100 nl, n = 6; sodium hydrosulfide (NaHS, a H S donor) 20, 200, or 2,000 µmol/l (n = 7 for each dose), and S-ademetionine (SAM; cystathionine-β- synthase agonist) 1 mmol/l (n = 7). Antagonist pretreatment control groups received NaHS (200 µmol/l) combined with 1 of the following agents: 1% dimethyl sulfoxide or aCSF (control; 100 nl; n = 6), kynurenic acid (glutamate receptor antagonist; 5 mmol/l; n = 7), hydroxy- lamine (cystathionine-β-synthase antagonist; 100 mmol/l; n = 7), or glibenclamide (K channel antagonist; n = 7). ATP 
TI - Abstract from the Chinese Journal of Hypertension
JO - American Journal of Hypertension
DO - 10.1093/ajh/hpu167
DA - 2014-10-12
UR - https://www.deepdyve.com/lp/oxford-university-press/abstract-from-the-chinese-journal-of-hypertension-fBSWi47d3n
SP - 1321
EP - 1321
VL - 27
IS - 10
DP - DeepDyve
ER -