TY - JOUR
AU - Li, Chenggang
AB - Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant. Efficient control of cancer growth may substantially improve the survival of PDAC patients. However, no efficient treatments are so far available. Here, we inhibited transforming growth factor β (TGFβ) receptor signaling by overexpression of a key inhibitor of this pathway, SMAD7, in the mouse pancreas, using a recently developed intraductal infusion method. Overexpression of SMAD7 significantly increased growth of both implanted PDAC and PDAC by K-ras modification. Our data thus suggest that TGFβ receptor signaling restrains growth of PDAC, and modulation of TGFβ receptor signaling may be an effective treatment for PDAC.
TI - RETRACTED ARTICLE: Transforming growth factor β receptor signaling restrains growth of pancreatic carcinoma cells
JF - Tumor Biology
DO - 10.1007/s13277-015-3466-3
DA - 2015-05-03
UR - https://www.deepdyve.com/lp/springer-journals/retracted-article-transforming-growth-factor-receptor-signaling-f0mRuHBQ0h
SP - 7711
EP - 7716
VL - 36
IS - 10
DP - DeepDyve
ER -