TY - JOUR AU1 - Lai, Shih-Wei AU2 - Lin, Cheng-Li AU3 - Liao, Kuan-Fu AB - Downloaded from https://pdfs.journals.lww.com/eurojgh by BhDMf5ePHKZxZb3ruX4b9cKfbT5h3bp+v9gTtSlrchDWvVTxyN8Hif2P/rPZfAxb8td684/2m6Qj/1S0ZObgiiKJ9vD64yNdY1wI1G/v4gN3ti1fujtTJsg5898WZFuC on 02/21/2019 Brief Report Proton pump inhibitors therapy and the risk of major osteoporotic nonhip fractures in older adults in Taiwan a,b a,c d,e Shih-Wei Lai , Cheng-Li Lin and Kuan-Fu Liao One article written by Islam et al. [1] reviewed the adverse and age-matched individuals without proton pump inhi- outcomes of long-term use of proton pump inhibitors. We bitors use were categorized as the nonuse group. The are interested in their findings on an increased risk of hip proton pump inhibitors-use group and the nonuse group fracture [odds ratio 1.42; 95% confidence interval (CI): were followed until a new diagnosis of major osteoporotic 1.33–1.53]. Moreover, conflicting data exist on this issue. nonhip fractures was made. Major osteoporotic nonhip One recent study reported that proton pump inhibitors use fractures included fractures of the spine, humerus, fore- of at least 1 year was associated with increased fracture arm, and wrist. During the cohort period, patients with hip risk in older adults (hazard ratio 1.27; 95% CI: 1.16–1.34) fractures were excluded from the study. Participants in [2]. However, one comment reported that proton pump whom the interval between the first-time prescription of inhibitors use was not TI - Proton pump inhibitors therapy and the risk of major osteoporotic nonhip fractures in older adults in Taiwan JF - European Journal of Gastroenterology & Hepatology DO - 10.1097/MEG.0000000000001312 DA - 2019-02-01 UR - https://www.deepdyve.com/lp/wolters-kluwer-health/proton-pump-inhibitors-therapy-and-the-risk-of-major-osteoporotic-efG38nnFG0 SP - 272 EP - 273 VL - 31 IS - 2 DP - DeepDyve ER -