TY - JOUR
AU1 - von Krogh, Geo
AU2 - Maibach, Howard I.
AB - Four lignans: podophyllotoxin (A), 4′-demethyl-podophyllotoxin (B), α-peltatin (C), and β-peltatin (D) are the podophyllin ingredients producing lesional necrosis after application on condylomata acuminata. This study evaluates comparatively their destructive potency on rabbit skin after 10-day repeated applications. Any visible changes or increase on skinfold thickness induced by each of the drugs tested as 0.01 0.05, 0.1 and 0.5% ethanolic preparations were followed. These variables demonstrated a close covariation; the analyses revealed a significant difference with respect to influence on measurements according to the following ranking order: A > C > D = B.
TI - Cutaneous Cytodestructive Potency of Lignans
JF - Dermatology
DO - 10.1159/000249751
DA - 1983-01-01
UR - https://www.deepdyve.com/lp/karger/cutaneous-cytodestructive-potency-of-lignans-ebx7fKndko
SP - 70
EP - 77
VL - 167
IS - 2
DP - DeepDyve
ER -