TY - JOUR
AU - MOSS, ROBERT, L.
AB - Abstract Administration of opioid receptor antagonists was utilized to determine the opioid receptor type involved in the suppression of LH release by β-endorphin (p–END). Long-term (three to four weeks) ovariectomized rats with chronic third ventricular cannulae were fitted with jugular catheters and received treatment with vehicle or one of three opioid antagonists. The 6 antagonist ICI 154,129, but not the μ1 or μ antagonists naloxazone or β-funaltrexamine, respectively, blocked the suppressive effect of p-END on plasma LH levels and transiently but significantly increased LH levels above preinfusion value. None of the antagonists significantly reduced the β-END-induced release of PRL. These results provide evidence that the inhibitory effect of β-END on LH release may be mediated by 6 receptors. This content is only available as a PDF. Author notes 1 This work was supported by a NIH Research Grant HD-11014 awarded To Robert L. Moss 2 Present address: Research Institute of Scripps Clinic. La Jolla, CA 92037. 3 Department cf Psychictry, University of Chicago School of Medicine, Chicago, Illinois 60637. Copyright © 1985 by The Endocrine Society
TI - POSSIBLE DELTA RECEPTOR MEDIATION OF THE EFFECT OF, β-ENDORPHIN ON LUTE IN IZ ING HORMONE (LH) RELEASE, BUT NOT ON PROLACTIN (PRL) RELEASE, IN THE OVARIECTOMI ZED RAT
JF - Endocrinology
DO - 10.1210/endo-116-1-475
DA - 1985-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/possible-delta-receptor-mediation-of-the-effect-of-endorphin-on-lute-eW4HGLzlJS
SP - 475
EP - 477
VL - 116
IS - 1
DP - DeepDyve
ER -