TY - JOUR
AU - WATANABE, Jun
AB - Abstract A simple preparation method for biocompatible nanoparticles in high concentration (0.5 wt %) by self-assembly of chitosan and carboxymethyl cellulose hydrolysates was developed. Chitosan and carboxymethyl cellulose were hydrolyzed beforehand with chitosanase and cellulase respectively to make fragments having lower molecular weights. Nanoparticles were spontaneously formed only by mixing the two hydrolysate solutions. The particle size distribution was relatively narrow, about 200 nm in mean size. The mean particle size decreased from 226 nm to 165 nm with decreasing molecular weight of chitosan hydrolysate from 9.5 to 6.8 kDa. The mixing ratio of chitosan and carboxymethyl cellulose hydrolysates also affected particle size. Changes in particle size are discussed in relation to a possible mechanism of polyionic complexation. 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PDF This content is only available as a PDF. © 2005 by Japan Society for Bioscience, Biotechnology, and Agrochemistry This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) © 2005 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
TI - Formation of Biocompatible Nanoparticles by Self-Assembly of Enzymatic Hydrolysates of Chitosan and Carboxymethyl Cellulose
JO - Bioscience Biotechnology and Biochemistry
DO - 10.1271/bbb.69.1637
DA - 2005-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/formation-of-biocompatible-nanoparticles-by-self-assembly-of-enzymatic-eOxPYkYLvf
SP - 1637
EP - 1642
VL - 69
IS - 9
DP - DeepDyve
ER -