TY - JOUR
AU1 - Doub, William
AU2 - Adams, Wallace
AU3 - Spencer, John
AU4 - Buhse, Lucinda
AU5 - Nelson, Matthew
AU6 - Treado, Patrick
AB - Good statistical agreement is obtained between the reported and measured sizes of the PS microspheres. BDP particles were clearly distinguishable from those of excipients. Raman chemical imaging (RCI) is able to differentiate between and identify the chemical makeup of multiple components in complex BDP sample and placebo mixtures. The Raman chemical imaging method (coupled Raman and optical imaging) shows promise as a method for characterizing particle size and shape of corticosteroid in aqueous nasal spray suspension formulations. However, rigorous validation of RCI for PSD analysis is incomplete and requires additional research effort. Some specific areas of concern are discussed.
TI - Raman Chemical Imaging for Ingredient-specific Particle Size Characterization of Aqueous Suspension Nasal Spray Formulations: A Progress Report
JF - Pharmaceutical Research
DO - 10.1007/s11095-006-9211-2
DA - 2007-03-20
UR - https://www.deepdyve.com/lp/springer-journals/raman-chemical-imaging-for-ingredient-specific-particle-size-eFmHHz8xXg
SP - 934
EP - 945
VL - 24
IS - 5
DP - DeepDyve
ER -