TY - JOUR
AU - Elias, Peter M.
AB - Abstract • Although the new synthetic retinoids are effective when administered systemically, they have not been shown to be effective as topical agents. We compared the topical activity of six synthetic retinoids (two arotinoids, etretinate, all-trans- and 13-cis-tetrazole-retinamide, isotretinoin, and tretinoin) on tail skin in the diazacholesterol-fed mouse model of ichthyosis. Responses were assessed clinically and by measurement of stratum corneum thickness. Although the arotinoids dramatically reduced scaling, they were toxic at concentrations above 0.1%, as was etretinate at 1.0% or greater. Lower concentrations were effective without producing local or systemic toxic reactions. Clinical responses were paralleled by equivalent decrements in stratum corneum thickness, which also permitted quantitative comparisons. The order of potency for the retinoids was as follows: arotinoids, etretinate, tetrazole-retinamides, tretinoin = isotretinoin, vehicle. These results demonstrate that (1) the synthetic retinoids hold promise as topical agents; (2) irritation is not an absolute requirement for topical retinoid activity; and (3) the diazcholesterol-fed mouse offers a new assay of topical retinoid potency in a well-defined animal model of ichthyosis. (Arch Dermatol 1984;120:342-347) References 1. Bollag W: Retinoids and cancer . Cancer Chemother Pharmacol 1979;3:207-215.Crossref 2. Elias PM, Williams ML: Retinoids, cancer and the skin . Arch Dermatol 1981;117:160-180.Crossref 3. Fritsch P: Oral retinoids in dermatology . Int J Dermatol 1981;20:314-329.Crossref 4. Lotan R: Effects of vitamin A and its analogues (retinoids) on normal and neoplastic cells . Biochim Biophys Acta 1980;605:33-91. 5. Peck GL: Retinoids in clinical dermatology . Prog Dis Skin 1981;1:227-269. 6. Sporn MB, Newton DL: Chemoprevention of cancer with retinoids . Fed Proc 1979;38:2328-2335. 7. Marcello C, Tong P: Epidermal keratinocyte growth: Changes in protein composition, synthesis, and keratins in differentiating cultures . J Invest Dermatol , in press. 8. Kubilus J, Rand R, Baden HP: Effects of retinoic acid and other retinoids on the growth and differentiation of 3T3-supported human keratinocytes . In Vitro 1981;17:786-795.Crossref 9. Yaar M, Stanley JR, Katz SI: Retinoic acid delays the terminal differentiation of keratinocytes in suspension culture . J Invest Dermatol 1981;76:363-366.Crossref 10. Elias PM, Fritsch PO, Lampe MA, et al: Retinoid effects on epidermal structure, differentiation, and permeability . Lab Invest 1981;44:531-540. 11. Lowe NJ, Stoughton RB: Essential fatty acid deficient hairless mouse: A model of chronic epidermal hyperproliferation . Br J Dermatol 1977;96:155-161.Crossref 12. Elias PM, Lampe MA, Chung JC, et al: Diazacholesterol- induced ichthyosis in the hairless mouse: Morphological, histochemical, and lipid biochemical characterization of a new animal model . Lab Invest 1983;48:565-577. 13. Elias PM, Williams ML, Lampe MA, et al: Drug-induced model of ichthyosis in hairless mice , abstracted. Clin Res 1982; 30:27A. 14. Anderson PC, Martt JM: Myotonia and keratoderma induced by 20,25-diazacholesterol . Arch Dermatol 1965;92:181-187.Crossref 15. Elias PM: Epidermal lipids, membranes, and keratinization . Int J Dermatol 1981;20:1-19.Crossref 16. Elias PM, Cooper ER, Korc A, et al: Percutaneous transport in relation to stratum corneum structure and lipid composition . J Invest Dermatol 1981;76:297-301.Crossref 17. Wrench R: Scale prophylaxis: A new antiparakeratotic assay . Arch Dermatol 1981;117:213-215.Crossref 18. Wrench R, Britten AZ: Evaluation of coal tar fractions for use in psoriasiform diseases using the mouse tail test . Br J Dermatol 1975;92:569-574.Crossref 19. Lowe N: Essential fatty acid deficient hairless mouse: Effects of topical agents . Br J Dermatol 1977;97:39-47.Crossref 20. Mezick JA, Chabria MC, Thorne EG, et al: Topical and oral (P.O.) effects of 13-cis-retinoic acid (13-cis-RA) and all-trans retinoic acid (RA) on horn-filled utriculi (pseudocomedones) size in the Rhino mouse , abstracted. Clin Res 1982;30:598A. 21. Mayer H, Bollag W, Hanni T, et al: Retinoids: A new class of compounds with prophylactic and therapeutic activities in oncology and dermatology . Experientia 1978;34:1105-1119.Crossref
TI - Diazacholesterol-Induced Ichthyosis in the Hairless Mouse: Assay for Comparative Potency of Topical Retinoids
JF - Archives of Dermatology
DO - 10.1001/archderm.1984.01650390064013
DA - 1984-03-01
UR - https://www.deepdyve.com/lp/american-medical-association/diazacholesterol-induced-ichthyosis-in-the-hairless-mouse-assay-for-eF0SO8uX0F
SP - 342
EP - 347
VL - 120
IS - 3
DP - DeepDyve
ER -