TY - JOUR
AU - Søballe, Kjeld
AB - Background Migration of wear debris to the periprosthetic bone is a major cause of osteolysis and implant failure. Both closed-pore porous coatings and hydroxyapatite (HA) coatings have been claimed to prevent the migration of wear debris. We investigated whether HA could augment the sealing effect of a porous coating under both stable and unstable conditions.Methods We inserted porous-surfaced knee implants, with and without HA coating, in 16 dogs, according to a paired, randomized study design. 8 dogs had 2 implants inserted into each knee using a stable implant device and 8 dogs received 1 implant in each knee using a micro-motion (500 μm) implant device. Implants had a periimplant gap of 0.75 mm. We then injected polyethylene (PE) particles or a control solution into the knee joints on a weekly basis.Results After 16 weeks, the rating of particles around stable implants was reduced by the HA coating from a median value of 2 (1–4) to 1 (0–1) (p = 0.01) and during micromotion from 3 (2–4) to 1 (0–3) (p = 0.002). HA-coated implants had superior bone ongrowth during stable and unstable conditions. We found no difference in bone ongrowth between PE-exposed and vehicle-exposed implants.Interpretation Compared to a pure plasma-sprayed porous coating, a layer of HA coating provides better bone ongrowth and protects the bone-implant interface against the migration of wear debris under both stable and unstable conditions.
TI - Superior sealing effect of hydroxyapatite in porous-coated implants
JF - Acta Orthopaedica
DO - 10.1080/00016470510030850
DA - 2005-01-01
UR - https://www.deepdyve.com/lp/taylor-francis/superior-sealing-effect-of-hydroxyapatite-in-porous-coated-implants-eE7Z0rsFmK
SP - 375
EP - 385
VL - 76
IS - 3
DP - DeepDyve
ER -