TY - JOUR
AU - Alexandrescu, R.
AB - Europ. Neurol. 2: 374-379 (1969) Spino-cerebellar degeneration Friedreich’s ataxia Serum electrophoresis Cerebrospinal fluid Protein profile G. B a d iu , F. C h e r c iu l e s c u and R. A l ex a n d rescu Institute of Neurology of the Academy of the Socialist Republic of Rumania, Bucharest (Dir.: Prof. A. K reindler) Biochemical investigations carried out in recent years have suggested that some spino-cerebellar degenerations (SCD) and more particularly Friedreich’s ataxia might involve a genetically determined enzyme defect manifesting itself in a derangement of a metabolic pathway within the central nervous system [R o b in so n , 1966]. M a rin escu and T re t ia c o ff have, as a matter of fact, shown since 1920 that ‘the pathologic process in Friedreich’s disease could be due to the disturbed metabolism of the nerv­ ous fibres and not to an inflammatory process’, underlining at the same time the fact that the combined sclerosis commonly described in this dis­ ease represents a primary alteration conditioned by an anomaly in the chemical organization of myelin of certain fibre systems. This presumed enzymatic defect in the nervous system has so 
TI - The 'Protein Profile' in Some Spino-Cerebellar Degenerations
JF - European Neurology
DO - 10.1159/000113813
DA - 1969-01-01
UR - https://www.deepdyve.com/lp/karger/the-protein-profile-in-some-spino-cerebellar-degenerations-dtKdoHf6U5
SP - 374
EP - 379
VL - 2
IS - 6
DP - DeepDyve
ER -