TY - JOUR
AU - Haselwandter, Christoph A.
AB - Membrane proteins and lipids can self-assemble into membrane protein polyhedral nanoparticles (MPPNs). MPPNs have a closed spherical surface and a polyhedral protein arrangement, and may offer a new route for structure determination of membrane proteins and targeted drug delivery. We develop here a general analytic model of how MPPN self-assembly depends on bilayer-protein interactions and lipid bilayer mechanical properties. We find that the bilayer-protein hydrophobic thickness mismatch is a key molecular control parameter for MPPN shape that can be used to bias MPPN self-assembly towards highly symmetric and uniform MPPN shapes. Our results suggest strategies for optimizing MPPN shape for structural studies of membrane proteins and targeted drug delivery.
TI - Controlling the shape of membrane protein polyhedra
JF - EPL
DO - 10.1209/0295-5075/117/58001
DA - 2017-03-01
UR - https://www.deepdyve.com/lp/iop-publishing/controlling-the-shape-of-membrane-protein-polyhedra-dsBcEYV141
SP - 58001
VL - 117
IS - 5
DP - DeepDyve
ER -