TY - JOUR
AU - Sangdee, Chaichan
AB - Background: Isoflavones from soybeans may provide some beneficial impacts on postmenopausal health. The purpose of this study was to compare the pharmacokinetics and bioavailability of plasma isoflavones (daidzein and genistein) after a single dose of orally administered soy beverage and soy extract capsules in postmenopausal Thai women. Methods: We conducted a randomized two-phase crossover pharmacokinetic study in 12 postmenopausal Thai women. In the first phase, each subject randomly received either 2 soy extract capsules (containing daidzin : genistin = 7.79 : 22.57 mg), or soy beverage prepared from 15 g of soy flour (containing daidzin : genistin = 9.27 : 10.51 mg). In the second phase, the subjects received an alternative preparation in the same manner after a washout period of at least 1 week. Blood samples were collected immediately before and at 0.5, 1, 2, 4, 6, 8, 10, 12, 24 and 32 h after administration of the soy preparation in each phase. Plasma daidzein and genistein concentrations were determined by using high performance liquid chromatography (HPLC). The pharmacokinetic parameters of daidzein and genistein, i.e. maximal plasma concentration (C ), time to maximal plasma max concentration (T ), area under the plasma concentration-time curve (AUC) and half-life (t 
TI - Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women
JF - BMC Clinical Pharmacology
DO - 10.1186/1472-6904-5-2
DA - 2005-03-03
UR - https://www.deepdyve.com/lp/springer-journals/pharmacokinetics-of-isoflavones-daidzein-and-genistein-after-ingestion-drsox0vtUa
SP - 1
EP - 10
VL - 5
IS - 1
DP - DeepDyve
ER -