TY - JOUR
AU - DeLeo, Vincent A.
AB - Abstract The CLINICAL SPECTRUM of human immunodeficiency virus (HIV) disease involving skin is broad and varied. It includes localized and generalized inflammatory processes, cutaneous and systemic infections, and malignancies.1 One interesting phenomenon that appears to occur in some patients with HIV infection is hypersensitivity to UV light resulting in a number of very different types of cutaneous diseases. With the recent articles on possible acceleration of HIV disease by UV light exposure,2-5 it would appear important for clinicians and scientists to explore and explain the role of solar radiation in HIV infection. Porphyria cutanea tarda (PCT)6-8 and photosensitive granuloma annulare (GA)9,10 are known to occur with HIV. With the article by Berger and Dahr on lichenoid photoeruptions in this issue of the Archives,11 along with our own experience at Columbia-Presbyterian Medical Center in New York City, several other presentations of HIV photosensitivity can be added. These References 1. Phillips TJ, Dover JS. Recent advances in dermatology . N Engl J Med. 1992; 326:167-178.Crossref 2. Zmudzka BZ, Strickland AG, Miller SA, Dall' Acqua F, Beer JZ. Activation of the HIV promoter by psoralens or angelicins in combination with UVA radiation . Photochem Photobiol. 1993;58:226-232.Crossref 3. Zmudzka BZ, Beer JZ. Activation of human immunodeficiency virus by ultraviolet radiation . Photochem Photobiol. 1990;52:1153-1162.Crossref 4. Olvey KM, Beer JZ, Zmudzka BZ. Effects of repeated UVB exposures on the human immunodeficiency virus promoter . Presented at the 20th Annual Meeting of the American Society for Photobiology; June 23, 1992; Marco Island, Fla. 5. Wallace BM, Lasker JS. Awakenings... UV light and HIV gene activation . Science. 1992;257:1211-1212.Crossref 6. Cohen PR, Suarez SM, DeLeo VA. Porphyria cutanea tarda in human immunodeficiency virus-infected patients . JAMA. 1990;264:1315-1316.Crossref 7. Boisseau AM, Couzigou P, Forestier JF, et al. Porphyria cutanea tarda associated with human immunodeficiency virus infection . Dermatologica. 1991; 182:155-159.Crossref 8. Cohen PR. Porphyria cutanea tarda in human immunodeficiency virus-seropositive men: case report and literature review . J AIDS. 1991;4:1112-1117. 9. Ghadially R, Sibbard RG, Walter JB, Haberman HF. Granuloma annulare in patients with human immunodeficiency virus infections . J Am Acad Dermatol. 1989;20:232-235.Crossref 10. Cohen PR, Grossman ME, Silvers DN, DeLeo VA. Generalized granuloma annulare located on sun-exposed areas in a human immunodefiency virus seropositive man with ultraviolet B photosensitivity . Arch Dermatol. 1990;126:830-831.Crossref 11. Berger TG, Dhar A. Lichenoid photoeruptions in human immunodeficiency virus infection . Arch Dermatol. 1994;130:609-613.Crossref 12. Cohen PR, DeLeo VA. Disorders of porphyria metabolism . In: Alper JC, ed. Genetic Disorders of the Skin. St Louis, Mo: Mosby—Year Book Inc; 1990:79-104. 13. Blauvelt A, Harris HR, Hogan DJ, Jimenz-Acosta F, Ponce I, Pardo RJ. Porphyria cutanea tarda and human immunodeficiency virus infection . Int J Der- matol. 1992;31:474-479. 14. Ong ELC, Ellis ME, McDowell D, et al. Porphyria cutanea tarda in association with the human immunodeficiency virus infection . Postgrad Med J. 1988;64: 956-957.Crossref 15. Herrero C, Vicente A, Bruguera M, et al. Is hepatitis C virus infection a trigger of porphyria cutanea tarda? Lancet. 1993;341:788-789.Crossref 16. Supapannachart N, Breneman DL, Linnemann CC. Isolation of human immunodeficiency virus type 1 in cutaneous blister fluid . Arch Dermatol. 1991;127: 198-200.Crossref 17. Suarez SM, Cohen PR, DeLeo VA. Bullous photosensitivity to naproxen: 'pseudoporphyria.' Arthritis Rheum. 1990;33:903-908.Crossref 18. Gilchrest B, Rowe JW, Mihm MC. Bullous dermatosis of hemodialysis . Ann Intern Med. 1975;83:480-483.Crossref 19. Farr PM, Marks JM, Diffey DL. Skin fragility and blistering due to use of sunbeds . BMJ. 1988;296:1708-1709.Crossref 20. Pappert A, Grossman M, DeLeo V. Photosensitivity as the presenting illness in four patients with human immunodeficiency viral infection . Arch Dermatol. 1994; 130;618-623.Crossref 21. Norris PG, Hawk JLM. Chronic actinic dermatitis: a unifying concept . Arch Dermatol. 1990;126:376-378.Crossref 22. Dahl M. Is actinic granuloma really granuloma annulare . Arch Dermatol. 1986; 122:39-40.Crossref 23. Cohen PR, Grossman ME, Silvers DN, DeLeo VA. Human immunodeficiency virus-associated granuloma annulare . Int J STD AIDS. 1991;2:168-171. 24. Huerter CJ, Bass J, Bergfeld WF, Tubbs RR. Perforating granuloma annulare in a patient with acquired imunodeficiency syndrome . Arch Dermatol. 1987; 123:1217-1220.Crossref 25. Umbert P, Belcher RW, Winkelmann RK. Lymphokines (MIF) in the serum of patients with sarcoidosis and cutaneous granuloma annulare . Br J Dermatol. 1976;95:481-485.Crossref 26. Clerici M, Hakim FT, Venzon DJ, et al. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals . J Clin Invest. 1993;91:759-765.Crossref 27. Grazzinelli RT, Makino M, Snapper CM, Morse HC. CD4+ subset regulation in viral infection . J Immunol. 1992;148:182-188. 28. Greenberg RG, Berger TG. Nail and mucocutaneous hyperpigmentation with azidothymidine therapy . J Am Acad Dermatol. 1990;22:327-330.Crossref 29. Hendrix JD, Greer KE. Cutaneous hyperpigmentation caused by systemic drugs . Int J Dermatol. 1992;31:458-466.Crossref 30. Drugs that cause photosensitivity . Med Lett Drugs Ther. 1986;28:51-52. 31. Valerie K, Rosenberg M. Chromatin structure implicated in activation of gene expression by ultraviolet light . New Biologist. 1990;2:712. 32. Stanley SK, Fauci A. UV-induced DNA damage as an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, C-fos, and metallothionein . Mol Cell Biol. 1989;9:5169. 33. Morrey JD, Bourn SM, Bunch TD, Sidwell RW, Rosen CA. HIV-1 LTR activation model: evaluation of various agents in skin of transgenic mice . J AIDS. 1992; 5:1195-1203. 34. Zmudzka BZ. Activation of HIV by UVB radiation and PUVA treatment in vitro: an evaluation of the safety of medical procedures and cosmetic applications . Photochem Photobiol. 1992;55:895-905.Crossref 35. Miller SA, Beer JZ, Strickland AG, Zmudzka BZ. Spectral effects in activation of the HIV promoter by PUVA . Photochem Photobiol. 1993;57:945.Crossref 36. Bisaccia E, Berger C, Klainer AS. Extracorporeal photophoresis in the treatment of AIDS-related complex: a pilot study . Ann Intern Med. 1990;113:270-275.Crossref 37. Bisaccia E, Berger C, DiSpaltro FX, Klainer AS. Extracorporeal photophoresis in the treatment of AIDS-related complex: extended trial . J AIDS. 1993;6:386-392. 38. Ranki A, Puska P, Mattinen S, Lagerstedt A, Krohn K. Effect of PUVA on immunologic and virologic findings in HIV-infected patients . J Am Acad Dermatol. 1991;24:404-410.Crossref 39. Belsito DV, Sanchez M, Meola T, Soter NA, Moy JA. Effect of therapeutic ultraviolet B (UVB) on selected immunologic parameters in patients with human immunodeficiency virus (HIV) in mice and humans . Photochem Photobiol. 1993; 57:755.Crossref 40. Horn TD, Morison WL, Farzadegan H, Zmudzka BZ, Beer JZ. The effects of ultraviolet radiation on HIV in humans: a pilot study . Clin Res. 1993;41:502A. Abstract.
TI - Clinical Manifestations of Photosensitivity in Patients With Human Immunodeficiency Virus Infection
JO - Archives of Dermatology
DO - 10.1001/archderm.1994.01690050098018
DA - 1994-05-01
UR - https://www.deepdyve.com/lp/american-medical-association/clinical-manifestations-of-photosensitivity-in-patients-with-human-dpv3QnKjYP
SP - 630
EP - 633
VL - 130
IS - 5
DP - DeepDyve
ER -