TY - JOUR
AU - Hadziselimovic, Faruk
AB - In their study on “Androgen Insensitivity Syndrome at Prepuberty: Marked Loss of Spermatogonial Cells at Early Childhood and Presence of Gonocytes up to Puberty,” Aliberti et al. [2017] made an important contribution towards understanding germ cell development in an androgen-insensitive microenvironment. The main patho-histological changes described are the persistence of gonocytes throughout childhood up until puberty.However, the following remarks should be considered. Postnatal gonocytes are smaller compared to spermatogonia and are located in the center of tubules. The ultrastructure of this cell type shows that the major part is occupied by a large round nucleus with 1 or 2 centrally located nucleoli. Their chromatin forms small clumps and is less dispersed than that of fetal spermatogonia. Occasionally, a typical structure could be observed, a cup-like formation representing a lifting of the nuclear membrane, the structure connected with the appearance of chromatid bodies frequently present in the cytoplasm of fetal spermatogonia. The narrow cytoplasm contains small round mitochondria of the tubules type. These mitochondria are larger than those of Sertoli cells but smaller than mitochondria found in spermatogonia. Gonocytes form pseudopodia-like processes with micropinocytotic vesicles directed towards the basal membrane [Seguchi and Hadziselimovic, 1974; Hadziselimovic, 1977; Paniagua and Nistal et 
TI - Commentary on the Article “Androgen Insensitivity Syndrome at Prepuberty: Marked Loss of Spermatogonial Cells at Early Childhood and Presence of Gonocytes up to Puberty” by Aliberti et al.
JF - Sexual Development
DO - 10.1159/000490212
DA - 2018-01-01
UR - https://www.deepdyve.com/lp/karger/commentary-on-the-article-androgen-insensitivity-syndrome-at-dphbm8fSGS
SP - 161
EP - 162
VL - 12
IS - 4
DP - DeepDyve
ER -