TY - JOUR
AU - Chen, Baixin
AB - Abstract Introduction Objective and subjective measures of excessive daytime sleepiness (EDS) appear to be related to different underlying mechanisms and clinical outcomes in sleep apnea patients (OSA). Delta electroencephalogram (EEG) power, an index of slow wave sleep, appears to be associated with physiological sleep propensity while high- frequency EEG activity (i.e., beta EEG power) is an index of cortical hyperarousal. We examined whether the patterns of relative EEG power differ in OSA patients with objective vs. subjective EDS. Methods We studied 43 OSA patients (55.80±6.27, 51.2% male) who underwent 8-hour in-lab polysomnography for 4 consecutive nights. We examined delta (0.39-3.91 Hz), low-beta (15.23-25.00 Hz) and high-beta (25.39-35.16 Hz) relative power at central EEG derivations during nonrapid eye movement (NREM) sleep. The mean values of 2nd and 3rd nights of EEG relative power were used. Objective EDS was defined as mean multiple sleep latency test values ≤ 8 minutes, while subjective EDS was defined as Epworth scale score > 10. Results After adjusting for age, gender and apnea-hypopnea index (AHI), OSA with objective EDS had significantly higher relative delta power during NREM sleep compared to OSA without objective EDS (82.50±2.69 vs. 76.03±1.43, p=0.045), while OSA with subjective EDS had significantly higher relative low-beta (1.95±0.15 vs. 1.37±0.15, p= 0.010) and marginally significantly higher high-beta power (0.56±0.05vs. 0.44±0.05, p=0.072) during NREM sleep compared to OSA without subjective EDS. Furthermore, OSA patients with objective EDS had significantly higher relative delta power (81.02±2.23 vs. 74.66±1.78, p=0.046) and lower relative low-beta power (1.38±0.24 vs. 2.08±0.19, p=0.043) during NREM sleep compared to those with subjective, but not objective EDS, after adjusting for age, gender and AHI. Conclusion Our findings suggest that OSA with objective EDS is associated with higher levels of physiological sleep propensity which may be associated with impaired arousal mechanisms whereas subjective complaint of daytime sleepiness/ fatigue is associated with cortical arousal during NREM. Support (If Any) NIH RO1 HL64415 This content is only available as a PDF. © Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) © Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.
TI - 0437 Differences of Electroencephalogram Activity during Nonrapid Eye Movement Sleep between Objective and Subjective Daytime Sleepiness in Sleep Apnea Patients
JF - SLEEP
DO - 10.1093/sleep/zsz067.436
DA - 2019-04-13
UR - https://www.deepdyve.com/lp/oxford-university-press/0437-differences-of-electroencephalogram-activity-during-nonrapid-eye-dXof6FgSNN
SP - A176
EP - A177
VL - 42
IS - Supplement_1
DP - DeepDyve
ER -