TY - JOUR
AU - Paul N. Hopkins
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OpenUrl CrossRef Medline Web of Science Previous Next Back to top About the Cover About the Cover Cover image Cover: Model for the enzymatic specificity of polysialic acid transfer to the neural cell adhesion molecule NCAM and the synaptic cell adhesion molecule SynCAM 1. Left : two mammalian polysialyltransferases, ST8Sia-II and ST8Sia-IV, are shown as blue and gold transmembrane molecules facing the Golgi lumen. Each independently transfers polysialic acid primarily to NCAM on its fifth immunoglobulin-like (lg-like) domain (gray oval) at the terminus of two specific N -linked glycans (black triangles). Interactions between each transferase and NCAM's first fibronectin type III repeat (gray cylinder) are required to position the enzyme active site. Middle : all three NCAM isoforms, which differ in their membrane and intracellular domains, are acceptors for polysialylation. Right : ST8Sia-II (blue) also adds polysialic acid to the first lg-like domain of SynCAM 1, targeted via interactions with the SynCAM's second lg-like domain. See Schnaar, Ronald L., Rita Gerardy-Schahn, and Herbert Hildebrandt. Physiol Rev 94: 461–518 , 2014. Table of Contents Back Matter (PDF) Ed Board (PDF) Front Matter (PDF) Article Abstract I. INTRODUCTION II. OVERVIEW OF ATHEROGENESIS III. FUNDAMENTAL SIGNALING PATHWAYS RELEVANT TO MULTIPLE STAGES OF ATHEROGENESIS IV. INITIATION OF ATHEROSCLEROSIS: ARTERIAL FLOW PATTERNS ESTABLISH THE DISTRIBUTION OF ATHEROSCLEROTIC LESIONS V. INITIATION OF ATHEROSCLEROSIS: ENDOTHELIAL ACTIVATION BY DYSLIPIDEMIA VI. INITIATION OF ATHEROSCLEROSIS: LEUKOCYTE TRANSMIGRATION AND ACTIVATION VII. CYTOKINES AND INNATE VERSUS ADAPTIVE IMMUNITY IN ATHEROGENESIS VIII. EFFECTS OF SELECTED RISK FACTORS ON INITIATION OF ATHEROSCLEROSIS IX. PROMOTION OF ATHEROSCLEROSIS X. PROGRESSION OF ATHEROSCLEROSIS XI. FURTHER PLAQUE DESTABILIZATION AND PRECIPITATION OF THROMBOSIS XII. PERSPECTIVES DISCLOSURES ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Physiological Reviews. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Molecular Biology of Atherosclerosis Message Subject (Your Name) has sent you a message from Physiological Reviews Message Body (Your Name) thought you would like to see the Physiological Reviews web site. Your Personal Message Print Citation Tools Molecular Biology of Atherosclerosis Paul N. Hopkins Physiological Reviews Jul 2013, 93 (3) 1317-1542; DOI: 10.1152/physrev.00004.2012 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share Molecular Biology of Atherosclerosis Molecular Biology of Atherosclerosis Paul N. Hopkins Physiological Reviews Jul 2013, 93 (3) 1317-1542; DOI: 10.1152/physrev.00004.2012 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section L-Type Ca V 1.2 Calcium Channels: From In Vitro Findings to In Vivo Function Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities Actin Dynamics, Architecture, and Mechanics in Cell Motility Show more Articles Related Articles Web of Science Scopus PubMed Google Scholar Cited By... 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TI - Molecular Biology of Atherosclerosis
JF - Physiological Reviews
DO - 10.1152/physrev.00004.2012
DA - 2013-07-01
UR - https://www.deepdyve.com/lp/the-american-physiological-society/molecular-biology-of-atherosclerosis-dJHzVloM3e
SP - 1317
VL - 93
IS - 3
DP - DeepDyve
ER -