TY - JOUR
AB - COVER PICTURE The cover picture shows a highly diverse peptide library displayed on cylindrical bacteriophage particles that also contain the cognate DNA. Libraries such as this can be used to identify specific ligands for essentially any protein of interest. Here, phage particles displaying peptides that bind vascular endothelial growth factor are selected from amongst a sea of billions of random sequences. Further information can be found in the Review by Sidhu and co-workers on p. 14 ff. (We thank David Wood and Christian Wiesmann for help in the preparation of the cover picture.) REVIEWS S. S. Sidhu,* W. J. Fairbrother, Peptides on show: Phage-display libraries present diverse K. Deshayes populations of polypeptides on phage particles that also contain the encoding DNA. Selections with immobilized target 14 ± 25 proteins can be used to isolate ligands with particular binding Exploring Protein ± Protein characteristics (see schematic representation), and the poly- Interactions with Phage peptide sequences can be decoded subsequently from the Display DNA. By permitting the combinatorial sampling of billions of ligands en masse, phage-display technology provides a pow- erful approach to the rapid exploration of protein ± protein interactions. FULL PAPERS Y. Vo-Hoang, L. Micouin,* OH Probing immunoregulatory potential: 
TI - Graphical Abstract: ChemBioChem 1/2003
JF - ChemBioChem
DO - 10.1002/cbic.200390013
DA - 2003-01-03
UR - https://www.deepdyve.com/lp/wiley/graphical-abstract-chembiochem-1-2003-d3wgDn6e5D
SP - 5
EP - 10
VL - 4
IS - 1
DP - DeepDyve
ER -