TY - JOUR
AU - Mu, Yangdong
AB - INTRODUCTIONModern medicine faces a major challenge pertaining to widespread antimicrobial resistance resulting from the abuse of traditional antibiotics, which has reduced their efficacy and poses a serious threat to human health (Deslouches et al., 2013). The exhaustion of the traditional antibiotic pipeline has prompted the evaluation of various alternate antimicrobial strategies.One of the most effective alternate antimicrobial strategies is antimicrobial peptides (AMPs), produced as non‐specific innate immune system compounds and found among all classes of life (Fjell et al., 2011). AMPs have several advantages, such as broad‐spectrum antibacterial activity, multiple targets, and reduced bacterial resistance (do Nascimento et al., 2011) when compared to classic antimicrobials. AMPs are reportedly effective against bacteria, viruses, fungi, parasites, moulds and tumour cells (Radek & Gallo, 2007; Tornesello et al., 2020; Zasloff, 2002), and the ability of individual AMPs to act against specific targets via multiple mechanisms decreases their sensitivity to resistance (Browne et al., 2020). In addition, AMPs may affect the regulation of both the innate and adaptive immune pathways (Lai & Gallo, 2009), and there is a growing body of evidence describing the development of novel AMPs and their therapeutic potential.Our group previously designed and optimized a novel AMP, DP7 (VQWRIRVAVIRK‐NH2), via an amino acid‐based prediction method. We demonstrated that 
TI - Antibacterial and antibiofilm activities of novel antimicrobial peptide DP7 against the periodontal pathogen Porphyromonas gingivalis
JF - Journal of Applied Microbiology
DO - 10.1111/jam.15614
DA - 2022-08-01
UR - https://www.deepdyve.com/lp/oxford-university-press/antibacterial-and-antibiofilm-activities-of-novel-antimicrobial-d08JJGL0B8
SP - 1052
EP - 1062
VL - 133
IS - 2
DP - DeepDyve
ER -