TY - JOUR
AU1 - Higgins, Guy
AU2 - Wang,  Yephat
AU3 - Corrigall,  William
AU4 - Sellers,  Edward
AB - 213 114 114 4 4 Guy A. Higgins Yephat Wang William A. Corrigall Edward M. Sellers Preclinical Pharmacology and Experimental Psychology Program, Addiction Research Foundation 33 Russell Street Toronto Departments of Pharmacology, Physiology and Medicine University of Toronto Toronto Ontario Canada Glaxo Unit of Behavioural Psychopharmacology University of Hertfordshire College Lane AL10 9AB Hatfield Herts UK Abstract The purpose of the present study was to examine the effects of the 5-HT 3 antagonists ondansetron and MDL72222, and the 5-HT releaser and reuptake inhibitor dexfenfluramine, on intravenous heroin self-administration by Wistar rats. Using separate squads of animals, two separate schedules of heroin reinforcement were used; a relatively low dose (0.03 mg/kg per infusion) made available under a FR5 schedule for 1 h each day, and a moderate heroin dose (0.1 mg/kg per infusion) available under a FR1 schedule for 2 h each day. Following the acquisition of stable levels of responding across days, both naloxone pretreatment (0.25 mg/kg SC) and halving the heroin infusion dose produced increases in operant responding for heroin at each concentration. Neither ondansetron (0.01–1 mg/kg SC) nor MDL72222 (0.1–3 mg/kg SC) pretreatment influenced heroin self-administration. Chronic treatment (5 day) of ondansetron (0.01–0.1 mg/kg) was similarly ineffective. However, dexfenfluramine (0.5–2.5 mg/kg IP) consistently reduced heroin self-administration at doses producing only modest decreases in food responding. These findings are in contrast to place conditioning studies, which show that 5-HT 3 antagonists but not indirect 5-HT agonists block a morphine-induced place preference. Reasons for such discrepancies remain to be determined.
TI - Influence of 5-HT 3 receptor antagonists and the indirect 5-HT agonist, dexfenfluramine, on heroin self-administration in rats
JF - Psychopharmacology
DO - 10.1007/BF02244992
DA - 1994-05-01
UR - https://www.deepdyve.com/lp/springer-journals/influence-of-5-ht-3-receptor-antagonists-and-the-indirect-5-ht-agonist-cvzOPtIxrS
SP - 611
EP - 619
VL - 114
IS - 4
DP - DeepDyve
ER -