TY - JOUR
AU - Leonard, Fred
AB - Abstract THE n-ALKYL-α-cyanoacrylate monomers have the ability to adhere to moist living tissues. Methyl-α-cyanoacrylate monomer, in particular, has been used since 1960 by many investigators as a tissue adhesive for various surgical procedures, although the monomer is not widely used in clinical surgery. This is because of two factors: histotoxicity and relative failure of adhesive versus suture techniques. It is our belief that the success of surgical application of the cyanoacrylate tissue adhesive is dependent on the new surgical techniques suitable for the use of monomers in addition to development of a better monomer(s). New techniques have been developed at this Institute using the higher homologous monomers. This paper evaluates the various higher homologous monomers used for the surgery of internal organs. (Table 1). A useful tissue adhesive must possess several properties. These are (1) shelf stability, (2) polymerization in the presence of moisture to a thin polymer film, (3) adequate References 1. Woodward, S.C., et al: Histotoxicity of Cyanoacrylate Tissue Adhesive in the Rat , Ann Surg 162: 113, 1965.Crossref 2. Collins, J.A., et al: Biological Substrates and Cure Rates of Cyanoacrylate Tissue Adhesives , Arch Surg 93:428, 1966.Crossref 3. Matsumoto, T., et al: N-alkyl-Alpha-Cyanoacrylate Monomers in Surgery: Speed of Polymerization and Method of their Application, Arch Surg, to be published. 4. Reynolds, R.C.; Fassett, D.W.; and Astill, B.D.: Absorption of Methyl-2-Cyanoacrylate-2-14C From Full-Thickness Skin Incision in the Guinea Pig and Its Fate in Vivo , J Surg Res 6:132, 1966.Crossref 5. Cameron, J.L., et al: The Degradation of Cyanoacrylate Tissue Adhesive , Surgery 58:2, 1965. 6. Matsumoto, T., et al: Intestinal Anastomosis using N-Butyl Cyanoacrylate Tissue Adhesive, Surgery, to be published.
TI - Higher Homologous Cyanoacrylate Tissue Adhesives in Surgery of Internal Organs
JF - Archives of Surgery
DO - 10.1001/archsurg.1967.01330120115022
DA - 1967-06-01
UR - https://www.deepdyve.com/lp/american-medical-association/higher-homologous-cyanoacrylate-tissue-adhesives-in-surgery-of-cuTvbT0zHS
SP - 861
EP - 864
VL - 94
IS - 6
DP - DeepDyve
ER -