TY - JOUR
AU - Becher, Georg
AB - A method has been developed for quantitation of a selection of halogenated flame retardants in human milk. The method has been validated for seven polybrominated diphenyl ethers (PBDEs), BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154, and BDE-183, and the halogenated phenols 2,4,6-tribromophenol (TriBP), pentabromophenol (PeBP), tetrachlorobisphenol-A (TCBP-A), and tetrabromobisphenol-A (TBBP-A). The sample preparation includes solid-phase extraction using an N-vinylpyrrolidone-divinylbenzene copolymer with on-column lipid decomposition followed by additional cleanup on sulfuric acid-silica columns and methylation of the phenolic compounds. Separation and detection were performed by gas chromatography-electron capture mass spectrometry, using a 5% phenyl 95% dimethylpolysiloxane column. The method has been validated in the range of 1.8–180 pg/g milk for most of the halogenated flame retardants. The average absolute recoveries were from 49 to 83%, and the average recoveries with respect to internal standards were in the range of 53 to 121%. Estimated limits of detection were in the range of 0.3 to 1.0 pg/g milk using a sample size of 5 g for all compounds, except TCBP-A, for which the limit of detection was estimated to 6.7 pg/g milk.
TI - A New Method for Determination of Halogenated Flame Retardants in Human Milk Using Solid-Phase Extraction
JO - Journal of Analytical Toxicology
DO - 10.1093/jat/26.3.129
DA - 2002-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/a-new-method-for-determination-of-halogenated-flame-retardants-in-csMq9YzDG9
SP - 129
EP - 137
VL - 26
IS - 3
DP - DeepDyve
ER -