TY - JOUR
AU - Birkhaug, Konrad E.
AB - METAPHEN 1. RESULTS OF THE USE OF METAPHEN IN EXPERIMENTAL SEPTICEMIA R. GORDON DOUGLAS AND KONRAD E. BIRKHAUG ROCHESTER, N. Y. Septicemias due to pneumococci and streptococci have long defied effective chemotherapy, although a legion of drugs has been employed for years. Clinicians have anxiously awaited an antiseptic substance, the antibacterial properties of which would be relatively high as com­ pared with its toxicity for mammalian tissues. A substance of this kind to which attention was drawn recently is metaphen, the anhydride of 4,nitro-S-hydroxy-mercuri-ortho cresol, C : CH The 2H 2 30NO z.Hg. unusual antiseptic and disinfectant properties of this organic compound in vitro have been adequately demonstrated by Raiziss and Severac,' Shamberg, Kolmer and Raiziss," Peterson," Branham," Malcolm 5 and Birkhaug." The high phenol coefficient of metaphen and its low toxicity in animals immediately suggested its usefulness in the clinic. Thus Scott and Birkhaug," in their comparative study of preoperative skin disinfectants, demonstrated that the alcohol-acetone-aqueous 0.5 per cent solution of metaphen was relatively free from the objectionable features of solutions of tincture of iodine and the alcohol-acetone-aqueous 2 per cent mercurochrome-220 soluble, and that it fulfilled under strictly con­ trolled conditions on animals and man the requirements 
TI - Metaphen: I. Results of the Use of Metaphen in Experimental Septicemia
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/53.1.55
DA - 1933-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/metaphen-i-results-of-the-use-of-metaphen-in-experimental-septicemia-csJTrUMWyf
SP - 55
EP - 70
VL - 53
IS - 1
DP - DeepDyve
ER -