TY - JOUR
AU - Darzynkiewicz, Edward
AB - The cap structure was discovered at the 5′-end of the eukaryotic mRNA over three and a half decades ago. Since then, hundreds of chemically modified cap analogs have been synthesized and applied in numerous studies on the elucidation of cap-related physiological processes in the cell, and became important members of the biophosphate family. In this Perspective, we present recent developments in the synthesis of cap analogs modified within 5′,5′-triphosphate bridges and their utility for interdisciplinary studies on cap-dependent processes in gene expression and its regulation, as well as biotechnological applications and perspectives in medicine.
TI - Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects
JF - NJC: New Journal of Chemistry
DO - 10.1039/c0nj00041h
DA - 2010-05-01
UR - https://www.deepdyve.com/lp/royal-society-of-chemistry/synthetic-mrna-cap-analogs-with-a-modified-triphosphate-bridge-cko4SPvGI0
SP - 829
EP - 844
VL - 34
IS - 5
DP - DeepDyve
ER -