TY - JOUR
AU - Tokuhisa,, Takeshi
AB - Abstract c-fos and c-jun gene products form a heterodimeric complex (AP-1) that regulates target gene expression by binding to a specific DNA sequence motif. In order to study a role of AP-1 (Fos/Jun) in growth and differentiation of immature B lineage cells, we have established and mated two independent transgenic mice carrying the mouse c-fos gene or the viral v-Jun gene fused to the H-2K promoter. IL-7 dependent bone marrow cell culture from doubly transgenic (H2-fos/jun) mice demonstrated severe delay of early B cell development. Proliferation of pre-B cells in the fresh bone marrow from HZ-fos/jun mice to IL-7 stimulation was very low. These results suggest that the deregulated production of AP-1 perturbs IL-7 mediated proliferation and differentiation of immature B cells. AP-1, c-jun, IL-7, stromal cells This content is only available as a PDF. © 1993 Oxford University Press
TI - B cell development is perturbed in bone marrow from c-fos/v-jun doubly transgenic mice
JO - International Immunology
DO - 10.1093/intimm/5.2.227
DA - 1993-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/b-cell-development-is-perturbed-in-bone-marrow-from-c-fos-v-jun-doubly-ch5KbCdBZe
SP - 227
EP - 230
VL - 5
IS - 2
DP - DeepDyve
ER -