TY - JOUR AU - Bongiovanni,, A.M. AB - Downloaded from https://academic.oup.com/humrep/article-abstract/10/11/2952/674261 by guest on 14 October 2019 Human Reproduction vol.10 no. II pp.2952-2955, 1995 Relationship between an asymptomatic male genital tract exposure to Chlamydia trachomatis and an autoimmune response to spermatozoa S.S.Witkin , I.Kligman and A.M.Bongiovanni Several studies, utilizing relatively small numbers of subjects, have identified a relationship between urethritis (Shahmanesh Division of Immunology and Infectious Diseases, Department of et ai, 1986) or a Chlamydia trachomatis male genital tract Obstetrics and Gynecology, Cornell University Medical College, infection (Close et ai, 1987; Soffer et al., 1990; Witkin et ai, 515 East 71st Street, New York, NY 10021, USA 1993) and antisperm antibodies. Because C.trachomatis male 'To whom correspondence should be addressed genital tract infections are often asymptomatic (Singh and Blackwell, 1994), the organism may persist undetected for The relationship between a localized genital tract humoral immune response to Chlamydia trachomatis and the pres- long periods of time. However, the chronic immune activation ence of antisperm antibodies on the surface of motile elicited by C.trachomatis within the genital tract may precipit- spermatozoa in the ejaculate was examined in 227 asympto- ate a sperm-directed autoimmune response. matic male partners of infertile couples with no history of We have demonstrated that TI - Relationship between an asymptomatic male genital tract exposure to Chlamydia trachomatis and an autoimmune response to spermatozoa JF - Human Reproduction DO - 10.1093/oxfordjournals.humrep.a135827 DA - 1995-11-01 UR - https://www.deepdyve.com/lp/oxford-university-press/relationship-between-an-asymptomatic-male-genital-tract-exposure-to-cbAwSCikdj SP - 2952 VL - 10 IS - 11 DP - DeepDyve ER -