TY - JOUR AU1 - Lei Xiao, Yahan Liu, Nanping Wang AB - REFERENCES 1. ↵ Aderem A , Ulevitch RJ . Toll-like receptors in the induction of the innate immune response . Nature 406 : 782 – 787 , 2000 . OpenUrl CrossRef Medline Web of Science 2. ↵ Aird WC . Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms . Circ Res 100 : 158 – 173 , 2007 . OpenUrl Abstract / FREE Full Text 3. ↵ Akashi-Takamura S , Miyake K . TLR accessory molecules . Curr Opin Immunol 20 : 420 – 425 , 2008 . OpenUrl CrossRef Medline Web of Science 4. ↵ Alexopoulou L , Holt AC , Medzhitov R , Flavell RA . Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 . Nature 413 : 732 – 738 , 2001 . OpenUrl CrossRef Medline Web of Science 5. ↵ Ando T , Langley RR , Wang Y , Jordan PA , Minagar A , Alexander JS , Jennings MH . Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion in vitro . BMC Physiol 7 : 10 , 2007 . OpenUrl CrossRef Medline 6. ↵ Asangani IA , Rasheed SA , Nikolova DA , Leupold JH , Colburn NH , Post S , Allgayer H . MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer . Oncogene 27 : 2128 – 2136 , 2008 . OpenUrl CrossRef Medline Web of Science 7. ↵ Basak S , Kim H , Kearns JD , Tergaonkar V , O'Dea E , Werner SL , Benedict CA , Ware CF , Ghosh G , Verma IM , Hoffmann A . A fourth IkappaB protein within the NF-kappaB signaling module . Cell 128 : 369 – 381 , 2007 . OpenUrl CrossRef Medline Web of Science 8. ↵ Berlin C , Bargatze RF , Campbell JJ , von Andrian UH , Szabo MC , Hasslen SR , Nelson RD , Berg EL , Erlandsen SL , Butcher EC . Alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow . Cell 80 : 413 – 422 , 1995 . OpenUrl CrossRef Medline Web of Science 9. ↵ Bomfim GF , Dos Santos RA , Oliveira MA , Giachini FR , Akamine EH , Tostes RC , Fortes ZB , Webb RC , Carvalho MH . Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats . Clin Sci (Lond) 122 : 535 – 543 , 2012 . OpenUrl CrossRef Medline 10. ↵ Bouwmeester T , Bauch A , Ruffner H , Angrand PO , Bergamini G , Croughton K , Cruciat C , Eberhard D , Gagneur J , Ghidelli S , Hopf C , Huhse B , Mangano R , Michon AM , Schirle M , Schlegl J , Schwab M , Stein MA , Bauer A , Casari G , Drewes G , Gavin AC , Jackson DB , Joberty G , Neubauer G , Rick J , Kuster B , Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat Cell Biol 6 : 97 – 105 , 2004 . OpenUrl CrossRef Medline Web of Science 11. ↵ Brand K , Eisele T , Kreusel U , Page M , Page S , Haas M , Gerling A , Kaltschmidt C , Neumann FJ , Mackman N , Baeurele PA , Walli AK , Neumeier D . Dysregulation of monocytic nuclear factor-kappa B by oxidized low-density lipoprotein . Arterioscler Thromb Vasc Biol 17 : 1901 – 1909 , 1997 . OpenUrl Abstract / FREE Full Text 12. ↵ Brevetti G , Giugliano G , Brevetti L , Hiatt WR . Inflammation in peripheral artery disease . Circulation 122 : 1862 – 1875 , 2010 . OpenUrl FREE Full Text 13. ↵ Butcher EC . Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity . Cell 67 : 1033 – 1036 , 1991 . OpenUrl CrossRef Medline Web of Science 14. ↵ Campbell JJ , Hedrick J , Zlotnik A , Siani MA , Thompson DA , Butcher EC . Chemokines and the arrest of lymphocytes rolling under flow conditions . Science 279 : 381 – 384 , 1998 . OpenUrl Abstract / FREE Full Text 15. ↵ Carr MW , Roth SJ , Luther E , Rose SS , Springer TA . Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant . Proc Natl Acad Sci USA 91 : 3652 – 3656 , 1994 . OpenUrl Abstract / FREE Full Text 16. ↵ Chan JR , Hyduk SJ , Cybulsky MI . Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration . J Exp Med 193 : 1149 – 1158 , 2001 . OpenUrl Abstract / FREE Full Text 17. ↵ Chen G , Goeddel DV . TNF-R1 signaling: a beautiful pathway . Science 296 : 1634 – 1635 , 2002 . OpenUrl Abstract / FREE Full Text 18. ↵ Chiu JJ , Chien S . Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives . Physiol Rev 91 : 327 – 387 , 2011 . OpenUrl Abstract / FREE Full Text 19. ↵ Coggins M , Rosenzweig A . The fire within: cardiac inflammatory signaling in health and disease . Circ Res 110 : 116 – 125 , 2012 . OpenUrl Abstract / FREE Full Text 20. ↵ Cook-Mills JM , Deem TL . Active participation of endothelial cells in inflammation . J Leukoc Biol 77 : 487 – 495 , 2005 . OpenUrl Abstract / FREE Full Text 21. ↵ Curtiss LK , Tobias PS . Emerging role of Toll-like receptors in atherosclerosis . J Lipid Res 50 , Suppl : S340 – 345 , 2009 . OpenUrl Abstract / FREE Full Text 22. ↵ Cybulsky MI , Allan-Motamed M , Collins T . Structure of the murine VCAM1 gene . Genomics 18 : 387 – 391 , 1993 . OpenUrl CrossRef Medline Web of Science 23. ↵ Dichtl W , Nilsson L , Goncalves I , Ares MP , Banfi C , Calara F , Hamsten A , Eriksson P , Nilsson J . Very low-density lipoprotein activates nuclear factor-kappaB in endothelial cells . Circ Res 84 : 1085 – 1094 , 1999 . OpenUrl Abstract / FREE Full Text 24. ↵ DiDonato JA , Hayakawa M , Rothwarf DM , Zandi E , Karin M . A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB . Nature 388 : 548 – 554 , 1997 . OpenUrl CrossRef Medline Web of Science 25. ↵ DiDonato JA , Mercurio F , Karin M . NF-kappaB and the link between inflammation and cancer . Immunol Rev 246 : 379 – 400 , 2012 . OpenUrl CrossRef Medline 26. ↵ Diebold SS , Kaisho T , Hemmi H , Akira S , Reis e Sousa C . Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA . Science 303 : 1529 – 1531 , 2004 . OpenUrl Abstract / FREE Full Text 27. ↵ Dunne JL , Ballantyne CM , Beaudet AL , Ley K . Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1 . Blood 99 : 336 – 341 , 2002 . OpenUrl Abstract / FREE Full Text 28. ↵ Esteller M . Non-coding RNAs in human disease . Nat Rev Genet 12 : 861 – 874 , 2011 . OpenUrl CrossRef Medline 29. ↵ Fang Y , Shi C , Manduchi E , Civelek M , Davies PF . MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro . Proc Natl Acad Sci USA 107 : 13450 – 13455 , 2010 . OpenUrl Abstract / FREE Full Text 30. ↵ Faustin B , Lartigue L , Bruey JM , Luciano F , Sergienko E , Bailly-Maitre B , Volkmann N , Hanein D , Rouiller I , Reed JC . Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation . Mol Cell 25 : 713 – 724 , 2007 . OpenUrl CrossRef Medline Web of Science 31. ↵ Fitzgerald KA , Palsson-McDermott EM , Bowie AG , Jefferies CA , Mansell AS , Brady G , Brint E , Dunne A , Gray P , Harte MT , McMurray D , Smith DE , Sims JE , Bird TA , O'Neill LA . Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction . Nature 413 : 78 – 83 , 2001 . OpenUrl CrossRef Medline Web of Science 32. ↵ Fleissner F , Jazbutyte V , Fiedler J , Gupta SK , Yin X , Xu Q , Galuppo P , Kneitz S , Mayr M , Ertl G , Bauersachs J , Thum T . Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism . Circ Res 107 : 138 – 143 , 2010 . OpenUrl Abstract / FREE Full Text 33. ↵ Franchi L , Warner N , Viani K , Nunez G . Function of Nod-like receptors in microbial recognition and host defense . Immunol Rev 227 : 106 – 128 , 2009 . OpenUrl CrossRef Medline Web of Science 34. ↵ Gay NJ , Gangloff M . Structure and function of Toll receptors and their ligands . Annu Rev Biochem 76 : 141 – 165 , 2007 . OpenUrl CrossRef Medline Web of Science 35. ↵ Harris TA , Yamakuchi M , Ferlito M , Mendell JT , Lowenstein CJ . MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1 . Proc Natl Acad Sci USA 105 : 1516 – 1521 , 2008 . OpenUrl Abstract / FREE Full Text 36. ↵ Hayashi F , Smith KD , Ozinsky A , Hawn TR , Yi EC , Goodlett DR , Eng JK , Akira S , Underhill DM , Aderem A . The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 . Nature 410 : 1099 – 1103 , 2001 . OpenUrl CrossRef Medline Web of Science 37. ↵ Hayden MS , Ghosh S . Signaling to NF-kappaB . Genes Dev 18 : 2195 – 2224 , 2004 . OpenUrl Abstract / FREE Full Text 38. ↵ Hergenreider E , Heydt S , Treguer K , Boettger T , Horrevoets AJ , Zeiher AM , Scheffer MP , Frangakis AS , Yin X , Mayr M , Braun T , Urbich C , Boon RA , Dimmeler S . Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs . Nat Cell Biol 14 : 249 – 256 , 2012 . OpenUrl CrossRef Medline Web of Science 39. ↵ Hiscott J , Kwon H , Genin P . Hostile takeovers: viral appropriation of the NF-kappaB pathway . J Clin Invest 107 : 143 – 151 , 2001 . OpenUrl CrossRef Medline Web of Science 40. ↵ Hornung V , Ablasser A , Charrel-Dennis M , Bauernfeind F , Horvath G , Caffrey DR , Latz E , Fitzgerald KA . AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC . Nature 458 : 514 – 518 , 2009 . OpenUrl CrossRef Medline Web of Science 41. ↵ Hsu H , Huang J , Shu HB , Baichwal V , Goeddel DV . TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex . Immunity 4 : 387 – 396 , 1996 . OpenUrl CrossRef Medline Web of Science 42. ↵ Hsu H , Xiong J , Goeddel DV . The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation . Cell 81 : 495 – 504 , 1995 . OpenUrl CrossRef Medline Web of Science 43. ↵ Imaeda AB , Watanabe A , Sohail MA , Mahmood S , Mohamadnejad M , Sutterwala FS , Flavell RA , Mehal WZ . Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome . J Clin Invest 119 : 305 – 314 , 2009 . OpenUrl Medline Web of Science 44. ↵ Inohara N , Nunez G . NODs: intracellular proteins involved in inflammation and apoptosis . Nat Rev Immunol 3 : 371 – 382 , 2003 . OpenUrl CrossRef Medline Web of Science 45. ↵ Jacobs MD , Harrison SC . Structure of an IkappaBalpha/NF-kappaB complex . Cell 95 : 749 – 758 , 1998 . OpenUrl CrossRef Medline Web of Science 46. ↵ Jefferies C , Bowie A , Brady G , Cooke EL , Li X , O'Neill LA . Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1 . Mol Cell Biol 21 : 4544 – 4552 , 2001 . OpenUrl Abstract / FREE Full Text 47. ↵ Jiang D , Liang J , Fan J , Yu S , Chen S , Luo Y , Prestwich GD , Mascarenhas MM , Garg HG , Quinn DA , Homer RJ , Goldstein DR , Bucala R , Lee PJ , Medzhitov R , Noble PW . Regulation of lung injury and repair by Toll-like receptors and hyaluronan . Nat Med 11 : 1173 – 1179 , 2005 . OpenUrl CrossRef Medline Web of Science 48. ↵ Jin C , Zhao Y , Yu L , Xu S , Fu G . MicroRNA-21 mediates the rapamycin-induced suppression of endothelial proliferation and migration . FEBS Lett 587 : 378 – 385 , 2013 . OpenUrl CrossRef Medline Web of Science 49. ↵ Kahlenberg JM , Thacker SG , Berthier CC , Cohen CD , Kretzler M , Kaplan MJ . Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus . J Immunol 187 : 6143 – 6156 , 2011 . OpenUrl Abstract / FREE Full Text 50. ↵ Karin M . The IkappaB kinase - a bridge between inflammation and cancer . Cell Res 18 : 334 – 342 , 2008 . OpenUrl CrossRef Medline Web of Science 51. ↵ Kawai T , Akira S . The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors . Nat Immunol 11 : 373 – 384 , 2010 . OpenUrl CrossRef Medline Web of Science 52. ↵ Khan BV , Parthasarathy SS , Alexander RW , Medford RM . Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells . J Clin Invest 95 : 1262 – 1270 , 1995 . OpenUrl CrossRef Medline Web of Science 53. ↵ Kim YJ , Hwang SJ , Bae YC , Jung JS . miR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue . Stem Cells 27 : 3093 – 3102 , 2009 . OpenUrl Medline Web of Science 54. ↵ King AE , Horne AW , Hombach-Klonisch S , Mason JI , Critchley HO . Differential expression and regulation of nuclear oligomerization domain proteins NOD1 and NOD2 in human endometrium: a potential role in innate immune protection and menstruation . Mol Hum Reprod 15 : 311 – 319 , 2009 . OpenUrl Abstract / FREE Full Text 55. ↵ Ley K , Laudanna C , Cybulsky MI , Nourshargh S . Getting to the site of inflammation: the leukocyte adhesion cascade updated . Nat Rev Immunol 7 : 678 – 689 , 2007 . OpenUrl CrossRef Medline Web of Science 56. ↵ Li D , Yang P , Xiong Q , Song X , Yang X , Liu L , Yuan W , Rui YC . MicroRNA-125a/b-5p inhibits endothelin-1 expression in vascular endothelial cells . J Hypertens 28 : 1646 – 1654 , 2010 . OpenUrl CrossRef Medline Web of Science 57. Li Z , Nabel GJ . A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription . Mol Cell Biol 17 : 6184 – 6190 , 1997 . OpenUrl Abstract / FREE Full Text 58. ↵ Lo SK , Lee S , Ramos RA , Lobb R , Rosa M , Chi-Rosso G , Wright SD . Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils . J Exp Med 173 : 1493 – 1500 , 1991 . OpenUrl Abstract / FREE Full Text 59. ↵ Luscinskas FW , Gimbrone MA Jr . . Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment . Annu Rev Med 47 : 413 – 421 , 1996 . OpenUrl CrossRef Medline Web of Science 60. ↵ Maher JJ . DAMPs ramp up drug toxicity . J Clin Invest 119 : 246 – 249 , 2009 . OpenUrl Medline Web of Science 61. ↵ Martinon F , Burns K , Tschopp J . The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta . Mol Cell 10 : 417 – 426 , 2002 . OpenUrl CrossRef Medline Web of Science 62. ↵ Matsuzawa A , Tseng PH , Vallabhapurapu S , Luo JL , Zhang W , Wang H , Vignali DA , Gallagher E , Karin M . Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex . Science 321 : 663 – 668 , 2008 . OpenUrl Abstract / FREE Full Text 63. ↵ Matzinger P . The danger model: a renewed sense of self . Science 296 : 301 – 305 , 2002 . OpenUrl Abstract / FREE Full Text 64. ↵ McEver RP , Beckstead JH , Moore KL , Marshall-Carlson L , Bainton DF . GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies . J Clin Invest 84 : 92 – 99 , 1989 . OpenUrl CrossRef Medline Web of Science 65. ↵ McEver RP , Cummings RD . Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment . J Clin Invest 100 : 485 – 491 , 1997 . OpenUrl CrossRef Medline Web of Science 66. ↵ Medzhitov R , Preston-Hurlburt P , Janeway CA Jr . . A human homologue of the Drosophila Toll protein signals activation of adaptive immunity . Nature 388 : 394 – 397 , 1997 . OpenUrl CrossRef Medline Web of Science 67. ↵ Meng F , Henson R , Wehbe-Janek H , Ghoshal K , Jacob ST , Patel T . MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer . Gastroenterology 133 : 647 – 658 , 2007 . OpenUrl CrossRef Medline Web of Science 68. ↵ Miles A , Liaskou E , Eksteen B , Lalor PF , Adams DH . CCL25 and CCL28 promote α 4 β 7 -integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow . Am J Physiol Gastrointest Liver Physiol 294 : G1257 – G1267 , 2008 . OpenUrl Abstract / FREE Full Text 69. ↵ Min W , Pober JS . TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways . J Immunol 159 : 3508 – 3518 , 1997 . OpenUrl Abstract 70. ↵ Mohan S , Mohan N , Sprague EA . Differential activation of NF-κB in human aortic endothelial cells conditioned to specific flow environments . Am J Physiol Cell Physiol 273 : C572 – C578 , 1997 . OpenUrl Abstract / FREE Full Text 71. ↵ Morigi M , Angioletti S , Imberti B , Donadelli R , Micheletti G , Figliuzzi M , Remuzzi A , Zoja C , Remuzzi G . Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-κB-dependent fashion . J Clin Invest 101 : 1905 – 1915 , 1998 . OpenUrl CrossRef Medline Web of Science 72. ↵ Muller DN , Mervaala EM , Schmidt F , Park JK , Dechend R , Genersch E , Breu V , Loffler BM , Ganten D , Schneider W , Haller H , Luft FC . Effect of bosentan on NF-kappaB, inflammation, and tissue factor in angiotensin II-induced end-organ damage . Hypertension 36 : 282 – 290 , 2000 . OpenUrl CrossRef 73. ↵ Mullick AE , Soldau K , Kiosses WB , Bell TA 3rd . , Tobias PS , Curtiss LK . Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events . J Exp Med 205 : 373 – 383 , 2008 . OpenUrl Abstract / FREE Full Text 74. ↵ Muzio M , Ni J , Feng P , Dixit VM . IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling . Science 278 : 1612 – 1615 , 1997 . OpenUrl Abstract / FREE Full Text 75. ↵ Naidu S , Wijayanti N , Santoso S , Kietzmann T , Immenschuh S . An atypical NF-kappaB-regulated pathway mediates phorbol ester-dependent heme oxygenase-1 gene activation in monocytes . J Immunol 181 : 4113 – 4123 , 2008 . OpenUrl Abstract / FREE Full Text 76. ↵ Nourshargh S , Krombach F , Dejana E . The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues . J Leukoc Biol 80 : 714 – 718 , 2006 . OpenUrl Abstract / FREE Full Text 77. ↵ Opitz B , Forster S , Hocke AC , Maass M , Schmeck B , Hippenstiel S , Suttorp N , Krull M . Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae . Circ Res 96 : 319 – 326 , 2005 . OpenUrl Abstract / FREE Full Text 78. ↵ Palmetshofer A , Robson SC , Nehls V . Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells . Thromb Haemost 82 : 1532 – 1537 , 1999 . OpenUrl Medline Web of Science 79. ↵ Park JS , Gamboni-Robertson F , He Q , Svetkauskaite D , Kim JY , Strassheim D , Sohn JW , Yamada S , Maruyama I , Banerjee A , Ishizaka A , Abraham E . High mobility group box 1 protein interacts with multiple Toll-like receptors . Am J Physiol Cell Physiol 290 : C917 – C924 , 2006 . OpenUrl Abstract / FREE Full Text 80. ↵ Parry GC , Mackman N . A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers . J Biol Chem 269 : 20823 – 20825 , 1994 . OpenUrl Abstract / FREE Full Text 81. ↵ Pober JS , Cotran RS . Cytokines and endothelial cell biology . Physiol Rev 70 : 427 – 451 , 1990 . OpenUrl FREE Full Text 82. ↵ Pober JS , Cotran RS . The role of endothelial cells in inflammation . Transplantation 50 : 537 – 544 , 1990 . OpenUrl CrossRef Medline Web of Science 83. ↵ Poltorak A , He X , Smirnova I , Liu MY , Van Huffel C , Du X , Birdwell D , Alejos E , Silva M , Galanos C , Freudenberg M , Ricciardi-Castagnoli P , Layton B , Beutler B . Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene . Science 282 : 2085 – 2088 , 1998 . OpenUrl Abstract / FREE Full Text 84. ↵ Pryshchep O , Ma-Krupa W , Younge BR , Goronzy JJ , Weyand CM . Vessel-specific Toll-like receptor profiles in human medium and large arteries . Circulation 118 : 1276 – 1284 , 2008 . OpenUrl Abstract / FREE Full Text 85. ↵ Pueyo ME , Gonzalez W , Nicoletti A , Savoie F , Arnal JF , Michel JB . Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress . Arterioscler Thromb Vasc Biol 20 : 645 – 651 , 2000 . OpenUrl Abstract / FREE Full Text 86. ↵ Qin X , Wang X , Wang Y , Tang Z , Cui Q , Xi J , Li YS , Chien S , Wang N . MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells . Proc Natl Acad Sci USA 107 : 3240 – 3244 , 2010 . OpenUrl Abstract / FREE Full Text 87. ↵ Rahman A , Fazal F . Blocking NF-kappaB: an inflammatory issue . Proc Am Thorac Soc 8 : 497 – 503 , 2011 . OpenUrl CrossRef Medline 88. ↵ Rothwarf DM , Zandi E , Natoli G , Karin M . IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex . Nature 395 : 297 – 300 , 1998 . OpenUrl CrossRef Medline Web of Science 89. ↵ Sabatel C , Malvaux L , Bovy N , Deroanne C , Lambert V , Gonzalez ML , Colige A , Rakic JM , Noel A , Martial JA , Struman I . MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells . PLoS One 6 : e16979 , 2011 . OpenUrl CrossRef Medline 90. ↵ Satoh M , Ishikawa Y , Minami Y , Takahashi Y , Nakamura M . Role of Toll like receptor signaling pathway in ischemic coronary artery disease . Front Biosci 13 : 6708 – 6715 , 2008 . OpenUrl Medline 91. ↵ Schaefer L , Babelova A , Kiss E , Hausser HJ , Baliova M , Krzyzankova M , Marsche G , Young MF , Mihalik D , Gotte M , Malle E , Schaefer RM , Grone HJ . The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages . J Clin Invest 115 : 2223 – 2233 , 2005 . OpenUrl CrossRef Medline Web of Science 92. ↵ Schroder K , Tschopp J . The inflammasomes . Cell 140 : 821 – 832 , 2010 . OpenUrl CrossRef Medline Web of Science 93. ↵ Seimon TA , Nadolski MJ , Liao X , Magallon J , Nguyen M , Feric NT , Koschinsky ML , Harkewicz R , Witztum JL , Tsimikas S , Golenbock D , Moore KJ , Tabas I . Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress . Cell Metab 12 : 467 – 482 , 2010 . OpenUrl CrossRef Medline Web of Science 94. ↵ Seong SY , Matzinger P . Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses . Nat Rev Immunol 4 : 469 – 478 , 2004 . OpenUrl CrossRef Medline Web of Science 95. ↵ Shu HB , Takeuchi M , Goeddel DV . The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex . Proc Natl Acad Sci USA 93 : 13973 – 13978 , 1996 . OpenUrl Abstract / FREE Full Text 96. ↵ Sigal A , Bleijs DA , Grabovsky V , van Vliet SJ , Dwir O , Figdor CG , van Kooyk Y , Alon R . The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment . J Immunol 165 : 442 – 452 , 2000 . OpenUrl Abstract / FREE Full Text 97. ↵ Silke J . The regulation of TNF signalling: what a tangled web we weave . Curr Opin Immunol 23 : 620 – 626 , 2011 . OpenUrl CrossRef Medline 98. ↵ Stade BG , Messer G , Riethmuller G , Johnson JP . Structural characteristics of the 5' region of the human ICAM-1 gene . Immunobiology 182 : 79 – 87 , 1990 . OpenUrl CrossRef Medline Web of Science 99. ↵ Stewart CR , Stuart LM , Wilkinson K , van Gils JM , Deng J , Halle A , Rayner KJ , Boyer L , Zhong R , Frazier WA , Lacy-Hulbert A , El Khoury J , Golenbock DT , Moore KJ . CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer . Nat Immunol 11 : 155 – 161 , 2010 . OpenUrl CrossRef Medline Web of Science 100. ↵ Su X , Ao L , Shi Y , Johnson TR , Fullerton DA , Meng X . Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4 . J Biol Chem 286 : 12213 – 12220 , 2011 . OpenUrl Abstract / FREE Full Text 101. ↵ Suarez Y , Wang C , Manes TD , Pober JS . Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation . J Immunol 184 : 21 – 25 , 2010 . OpenUrl Abstract / FREE Full Text 102. ↵ Sun X , Icli B , Wara AK , Belkin N , He S , Kobzik L , Hunninghake GM , Vera MP , Blackwell TS , Baron RM , Feinberg MW . MicroRNA-181b regulates NF-kappaB-mediated vascular inflammation . J Clin Invest 122 : 1973 – 1990 , 2012 . OpenUrl Medline Web of Science 103. ↵ Thum T , Gross C , Fiedler J , Fischer T , Kissler S , Bussen M , Galuppo P , Just S , Rottbauer W , Frantz S , Castoldi M , Soutschek J , Koteliansky V , Rosenwald A , Basson MA , Licht JD , Pena JT , Rouhanifard SH , Muckenthaler MU , Tuschl T , Martin GR , Bauersachs J , Engelhardt S . MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts . Nature 456 : 980 – 984 , 2008 . OpenUrl CrossRef Medline Web of Science 104. ↵ Ting JP , Lovering RC , Alnemri ES , Bertin J , Boss JM , Davis BK , Flavell RA , Girardin SE , Godzik A , Harton JA , Hoffman HM , Hugot JP , Inohara N , Mackenzie A , Maltais LJ , Nunez G , Ogura Y , Otten LA , Philpott D , Reed JC , Reith W , Schreiber S , Steimle V , Ward PA . The NLR gene family: a standard nomenclature . Immunity 28 : 285 – 287 , 2008 . OpenUrl CrossRef Medline Web of Science 105. ↵ Tobias PS , Curtiss LK . Toll-like receptors in atherosclerosis . Biochem Soc Trans 35 : 1453 – 1455 , 2007 . OpenUrl CrossRef Medline Web of Science 106. ↵ Tousoulis D , Kampoli AM , Papageorgiou N , Androulakis E , Antoniades C , Toutouzas K , Stefanadis C . Pathophysiology of atherosclerosis: the role of inflammation . Curr Pharm Des 17 : 4089 – 4110 , 2011 . OpenUrl CrossRef Medline 107. ↵ Verma IM , Stevenson JK , Schwarz EM , Van Antwerp D , Miyamoto S . Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation . Genes Dev 9 : 2723 – 2735 , 1995 . OpenUrl FREE Full Text 108. ↵ Viglianti GA , Lau CM , Hanley TM , Miko BA , Shlomchik MJ , Marshak-Rothstein A . Activation of autoreactive B cells by CpG dsDNA . Immunity 19 : 837 – 847 , 2003 . OpenUrl CrossRef Medline Web of Science 109. ↵ Vince JE , Chau D , Callus B , Wong WW , Hawkins CJ , Schneider P , McKinlay M , Benetatos CA , Condon SM , Chunduru SK , Yeoh G , Brink R , Vaux DL , Silke J . TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha . J Cell Biol 182 : 171 – 184 , 2008 . OpenUrl Abstract / FREE Full Text 110. ↵ Wegmann F , Petri B , Khandoga AG , Moser C , Khandoga A , Volkery S , Li H , Nasdala I , Brandau O , Fassler R , Butz S , Krombach F , Vestweber D . ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability . J Exp Med 203 : 1671 – 1677 , 2006 . OpenUrl Abstract / FREE Full Text 111. ↵ Woronicz JD , Gao X , Cao Z , Rothe M , Goeddel DV . IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK . Science 278 : 866 – 869 , 1997 . OpenUrl Abstract / FREE Full Text 112. ↵ Xiang M , Shi X , Li Y , Xu J , Yin L , Xiao G , Scott MJ , Billiar TR , Wilson MA , Fan J . Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells . J Immunol 187 : 4809 – 4817 , 2011 . OpenUrl Abstract / FREE Full Text 113. ↵ Yamamoto M , Sato S , Hemmi H , Uematsu S , Hoshino K , Kaisho T , Takeuchi O , Takeda K , Akira S . TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway . Nat Immunol 4 : 1144 – 1150 , 2003 . OpenUrl CrossRef Medline Web of Science 114. ↵ Yelamanchili SV , Chaudhuri AD , Chen LN , Xiong H , Fox HS . MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease . Cell Death Dis 1 : e77 , 2010 . OpenUrl CrossRef Medline 115. ↵ Zernecke A , Bidzhekov K , Noels H , Shagdarsuren E , Gan L , Denecke B , Hristov M , Koppel T , Jahantigh MN , Lutgens E , Wang S , Olson EN , Schober A , Weber C . Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection . Sci Signal 2 : ra81 , 2009 . OpenUrl Abstract / FREE Full Text 116. ↵ Zhan Y , Brown C , Maynard E , Anshelevich A , Ni W , Ho IC , Oettgen P . Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling . J Clin Invest 115 : 2508 – 2516 , 2005 . OpenUrl CrossRef Medline Web of Science 117. ↵ Zhang SQ , Kovalenko A , Cantarella G , Wallach D . Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation . Immunity 12 : 301 – 311 , 2000 . OpenUrl CrossRef Medline Web of Science 118. ↵ Zhang Y , Liu D , Chen X , Li J , Li L , Bian Z , Sun F , Lu J , Yin Y , Cai X , Sun Q , Wang K , Ba Y , Wang Q , Wang D , Yang J , Liu P , Xu T , Yan Q , Zhang J , Zen K , Zhang CY . Secreted monocytic miR-150 enhances targeted endothelial cell migration . Mol Cell 39 : 133 – 144 , 2010 . OpenUrl CrossRef Medline Web of Science 119. ↵ Zhao H , Kalota A , Jin S , Gewirtz AM . The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells . Blood 113 : 505 – 516 , 2009 . OpenUrl Abstract / FREE Full Text 120. ↵ Zhou J , Wang KC , Wu W , Subramaniam S , Shyy JY , Chiu JJ , Li JY , Chien S . MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation . Proc Natl Acad Sci USA 108 : 10355 – 10360 , 2011 . OpenUrl Abstract / FREE Full Text 121. ↵ Zhu MT , Wang B , Wang Y , Yuan L , Wang HJ , Wang M , Ouyang H , Chai ZF , Feng WY , Zhao YL . Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis . Toxicol Lett 203 : 162 – 171 , 2011 . OpenUrl CrossRef Medline 122. ↵ Zhu N , Zhang D , Chen S , Liu X , Lin L , Huang X , Guo Z , Liu J , Wang Y , Yuan W , Qin Y . Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration . Atherosclerosis 215 : 286 – 293 , 2011 . OpenUrl CrossRef Medline Web of Science Previous Next Back to top About the Cover About the Cover Cover image Image 1: Wen Su, Zhongwen Xie, Liu Shu, Lindsay E. Caderon, Zhenheng Guo, and Ming Cui Gong. Smooth muscle-selective CPI-17 expression increases vascular smooth muscle contraction and blood pressure . Am J Physiol Heart Circ Physiol ; published ahead of print April 19, 2013, doi:10.1152/ajpheart.00597.2012. Image 2: Rebecca M. Smith, Ramjay Visweswaran, Iryna Talkachova, Jillian K. Wothe, and Elena G. Tolkacheva. Uncoupling the mitochondria facilitates alternans formation in the isolated rabbit heart . Am J Physiol Heart Circ Physiol ; published ahead of print May 3, 2013, doi:10.1152/ajpheart.00915.2012. Image 3: Heidi M. Medford, Karen Porter, and Susan A. Marsh. Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy . Am J Physiol Heart Circ Physiol ; published ahead of print April 26, 2013, doi:10.1152/ajpheart.00135.2013. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords inflammation endothelium signaling Inflammasome microRNA Article Abstract GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Heart and Circulatory Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following New paradigms in inflammatory signaling in vascular endothelial cells Message Subject (Your Name) has sent you a message from Heart and Circulatory Physiology Message Body (Your Name) thought you would like to see the Heart and Circulatory Physiology web site. Your Personal Message Print Citation Tools New paradigms in inflammatory signaling in vascular endothelial cells Lei Xiao , Yahan Liu , Nanping Wang American Journal of Physiology - Heart and Circulatory Physiology Feb 2014, 306 (3) H317-H325; DOI: 10.1152/ajpheart.00182.2013 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share New paradigms in inflammatory signaling in vascular endothelial cells New paradigms in inflammatory signaling in vascular endothelial cells Lei Xiao , Yahan Liu , Nanping Wang American Journal of Physiology - Heart and Circulatory Physiology Feb 2014, 306 (3) H317-H325; DOI: 10.1152/ajpheart.00182.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Endothelial nitric oxide synthase increases in left atria of dogs with pacing-induced heart failure Temperature dependence of early and late currents in human cardiac wild-type and long Q-T ΔKPQ Na + channels Effects of aging on sarcoplasmic reticulum Ca 2+ -cycling proteins and their phosphorylation in rat myocardium Show more CARDIAC PHYSIOLOGY Related Articles No related articles found. Web of Science PubMed Google Scholar Cited By... Investigating cardiac energetics in heart failure Abstract Fulltext PDF Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific Abstract Fulltext PDF 31P-NMR observation of free ADP during fatiguing, repetitive contractions of murine skeletal muscle lacking AK1 Abstract Fulltext PDF Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis Abstract Fulltext PDF Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to creatine kinase Abstract Fulltext PDF Subcellular Creatine Kinase Alterations : Implications in Heart Failure Abstract Fulltext PDF Transgenic Expression of Sarcoplasmic Reticulum Ca2+ ATPase Modifies the Transition From Hypertrophy to Early Heart Failure Abstract Fulltext PDF Web of Science (27) Google Scholar Calls for Papers Most Cited Most Read Cardiovascular Consequences of Obesity and Type 2 Diabetes Submission Deadline September 15, 2014 Autophagy in the Cardiovascular System Submission Deadline September 15, 2014 Featured Articles Featured Podcasts Rapid electrical stimulation causes alterations in cardiac intercellular junction proteins of cardiomyocytes Aerobic exercise acutely prevents the endothelial dysfunction induced by mental stress among subjects with metabolic syndrome: the role of shear rate Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers Sex differences in the pulmonary circulation: implications for pulmonary hypertension Adverse Perinatal Environment Contributes to Altered Cardiac Development and Function Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function Collections Call for Papers: Pathophysiology of Hypertension GA_googleFillSlot("ajpheart_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethical Policies PubMed Central Policy Reprints and Permissions Institutional Administrators American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Review Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org American Journal of Physiology - Heart and Circulatory Physiology® and the APS® logo are registered trademarks of the American Physiological Society | Print ISSN: 0363-6135 | Online ISSN: 1522-1539 TI - New paradigms in inflammatory signaling in vascular endothelial cells JF - AJP - Heart and Circulatory Physiology DO - 10.1152/ajpheart.00182.2013 DA - 2014-02-01 UR - https://www.deepdyve.com/lp/the-american-physiological-society/new-paradigms-in-inflammatory-signaling-in-vascular-endothelial-cells-cYWNkzeGoQ SP - H317 VL - 306 IS - 3 DP - DeepDyve ER -