TY - JOUR
AU - BISHOP, P. M. F.
AB - CLOMIPHENE P. M. F. Bishop 2. History of Early Clinical Studies Kistner & Smith (1960, 1961) reported induction of ovu- lation and pregnancies in four patients suffering from the Stein-Leventhal syndrome after administration of a non- steroidal oestrogenic antagonist MER-251, a compound closely related chemically to clomiphene, which was originally coded as MER-41. Greenblatt, Barfield, Jungck & Ray P. M. F. BISHOP D.M. F.R.C.P. F.R.C.O.G. (1961) and Tyler, Winer, Gotlib, Olson & Nakabayashi (1962) showed that clomiphene could induce ovulation in Guy's Hospital, London patients suffering from secondary amenorrhoea. Institute of Obstetrics and Gynaecology Hammersmith Hospital, London 3 . Selection of Patients The only function of clomiphene is to induce ovulation. 1 Chemistry and pharmacology Provided the woman's pituitary gland is capable of producing 2 History of early clinical studies 3 Selection of patients gonadotrophins, clomiphene has a reasonable chance of 4 Mode of action enabling her to discharge them in a ratio that will induce a Urinary oestrogen estimations ovulation. One should therefore estimate the urinary output b Electroencephalographic observations of gonadotrophins, and this can be carried out by the Results of administration of clomiphene Dosage control Johnsen (1958) modification of the Klinefelter method. a Basal temperature records 
TI - CLOMIPHENE
JF - British Medical Bulletin
DO - 10.1093/oxfordjournals.bmb.a070737
DA - 1970-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/clomiphene-cVMrLI4ESh
SP - 22
EP - 25
VL - 26
IS - 1
DP - DeepDyve
ER -