TY - JOUR
AU - Amyes, Sebastian G., B.
AB - Abstract Ampicillin and its derivatives are the most widely used β-lactam antibiotics throughout the world. Ampicillin resistance in Gram-negative bacteria is usually manifested by plasmid-encoded β-lactamases, which hydrolyse the β-lactam ring of the antibiotic. There are at least 30 different plasmid-encoded β-lactamases but almost all of them are found very infrequently. The one exception is the TEM-1 β-lactamase which is found wherever transferable ampicillin resistance emerges and accounts for over 50% of all plasmid encoded ampicillin resistance. In India, the incidence of ampicillin resistance is high (82%) and, amongst Escherichia coli, a significant proportion of the plasmid-encoded β-lactamases are different from those found in the United Kingdom. Although many Gram-negative species are able to accept the TEM-1 β-lactamase, certain species have a pre-disposition to their own plasmid β-lactamase types. References Abraham and Chain, 1940 Abraham E. , Chain E. . 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TI - Antibiotic resistance in the tropics 1. The genetics of bacterial ampicillin resistance in tropical areas
JF - Transactions of The Royal Society of Tropical Medicine and Hygiene
DO - 10.1016/0035-9203(89)90699-8
DA - 1989-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/antibiotic-resistance-in-the-tropics-1-the-genetics-of-bacterial-cUC0TKTkLC
SP - 38
EP - 41
VL - 83
IS - 1
DP - DeepDyve
ER -