TY - JOUR
AU - Butler, D. E.
AB - Pramiracetam hydrochloride, N‐(2‐(bis(1‐methylethyl)amino) ethyl)‐2‐oxo‐1‐pyrrolidineacetamide hydrochloride, CI‐879, a new potential clinically useful cognition activator, was labeled with 14C. Bromoacetic‐2‐14C acid was converted to its ethyl ester which reacted with sodium 2‐pyrrolidinone to yield ethyl 2‐oxo‐1‐pyrrolidineacetate‐α‐14C acid. Treatment of the latter with N,N‐bis(1‐methylethyl)‐1,2‐ethanediamine gave pramiracetam free base which was subsequently converted to the hydrochloride salt.
TI - Synthesis of 14 C‐labeled pramiracetam hydrochloride, N ‐(2‐(bis(1‐methylethyl)amino)ethyl)‐2‐oxo‐1‐pyrrolidine‐acetamide‐α‐ 14 C hydrochloride, CI‐879 hydrochloride
JO - Journal of Labelled Compounds and Radiopharmaceuticals
DO - 10.1002/jlcr.2580210409
DA - 1984-04-01
UR - https://www.deepdyve.com/lp/wiley/synthesis-of-14-c-labeled-pramiracetam-hydrochloride-n-2-bis-1-cMq1vbvgzV
SP - 347
EP - 352
VL - 21
IS - 4
DP - DeepDyve
ER -