TY - JOUR
AU - AMYES, S G B
AB - British Medical Bulletin (1984) Vol. 40, No. 1, pp. PLASMID-MEDIATED RESISTANCE TO ANTIFOLATE AGENTS J T Smith & SG B Amyes complete cessation of metabolism. This probably stems from the fact that extensive duplication of biochemical pathways would result in an unacceptable drain on the cell's resources. There is one pathway, however, where duplication may not overburden the cell and that is the synthesis of tetrahydrofolic acid. Tetrahydrofolic BACTERIAL RESISTANCE TO acid derivatives are used in living cells to donate single carbon ANTIFOLATE CHEMOTHERAPEUTIC fragments in anabolic metabolism which result in the de novo biosynthesis of several amino acids for protein synthesis and of AGENTS MEDIATED BY PLASMIDS several nucleotides for DNA and RNA synthesis. The ability to synthesize tetrahydrofolic acid from basic constituents is, however, J T SMITH BPharm PhD FPS confined to bacteria. This pathway is shown in Fig. 1. The condensation of 2-amino-4-hydroxy-6-hydroxymethyl-pteridine Microbiology Section with /vaminobenzoic acid (PABA) by dihydropteroate synthase Department of Pharmaceutics and of the resultant dihydropteroic acid with glutamic acid by The School of Pharmacy dihydrofolate synthase occurs only in bacteria. Mammalian cells, University of London which also require folic acid derivatives, do not exhibit this de novo synthesis but utilize preformed 
TI - BACTERIAL RESISTANCE TO ANTIFOLATE CHEMOTHERAPEUTIC AGENTS MEDIATED BY PLASMIDS
JO - British Medical Bulletin
DO - 10.1093/oxfordjournals.bmb.a071946
DA - 1984-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/bacterial-resistance-to-antifolate-chemotherapeutic-agents-mediated-by-cL77hnMtfF
SP - 42
EP - 46
VL - 40
IS - 1
DP - DeepDyve
ER -