TY - JOUR
AU1 - Nungester, W. J.
AU2 - Kempf, Alice H.
AB - THE USE OF EXPERIMENTAL PNEUMONIA IN RATS FOR THE EVALUATION OF THERAPEUTIC PROCEDURES W. J. NUNGESTER AND ALICE H. KEMPF From the Hygienic Laboratory, University of Michigan, Ann Arbor, Michigan Various methods have been used in the evaluation of antiserum for thera­ peutic use in pneumococcus pneumonia. This form of therapy has been fairly well evaluated in the treatment of human beings.' Such experiments are difficult to perform. The need for control groups with an expected higher mortality is not a pleasant phase of the work, and is one to be avoided when possible. The varying conditions of age, general health, etc., of the patients in such studies indicate the need for including a very large number of patients in such experiments to validate any conclusions. The bacteria infecting the patient varies not only as to type, but also as to virulence of strains within a type. Such variation may be avoided in experimental infections. Mouse protection tests" have a great deal to offer as a simple and effective way of determining certain protective properties of antiserum. Such tests serve a valuable function in standardizing antipneumococcus serum. How­ ever, they do not parallel the conditions encountered in the treatment 
TI - The use of Experimental Pneumonia in Rats for the Evaluation of Therapeutic Procedures
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/64.3.288
DA - 1939-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-use-of-experimental-pneumonia-in-rats-for-the-evaluation-of-c96GnNK1VB
SP - 288
EP - 292
VL - 64
IS - 3
DP - DeepDyve
ER -