TY - JOUR
AB - Editor Norman K. Hollenberg, MD, PhD Harvard Medical School, Brigham and Women’s Hospital, Department of Radiology, 15 Francis Street, Boston, MA 02115, USA. E-mail: djpagecapo@rics.bwh.harvard.edu Huang Y, Wongamorntham S, Kasting J, et al.: Renin increases mesangial cell transforming growth factor-ß1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 2006, 69:105–113. Abstract: Recent evidence suggesting a strong interplay between components of the renin- angiotensin system and key mediators of fibrosis led us to hypothesize that renin, independent of its enzymatic action to enhance angiotensin (Ang) II synthesis, directly increases production of the fibrogenic cytokine transforming growth factor (TGF)-β. Human or rat mesangial cells (MCs) were treated with human recombinant renin (HrRenin) or rat recombinant renin (RrRenin), and the effects on TGF-β1, plasminogen activator inhibitor-type 1 (PAI-1), fibronectin (FN), and col- lagen 1 mRNA and protein were investigated. Blockade of the rat MC renin receptor was achieved using siRNA. HrRenin or RrRenin, at doses shown to be physiologically relevant, induced marked dose- and time-dependent increases in TGF-β1. These effects were not altered by adding an inhibitor of renin’s enzymatic action (RO 42-5892), the Ang II receptor antagonist losartan, or the Ang-converting enzyme inhibitor enalapril. RrRenin also induced PAI-1, FN 
TI - Literature alert
JF - Current Hypertension Reports
DO - 10.1007/s11906-006-0017-8
DA - 2006-05-17
UR - https://www.deepdyve.com/lp/springer-journals/literature-alert-c3UP01nhVg
SP - 435
EP - 436
VL - 8
IS - 6
DP - DeepDyve
ER -