TY - JOUR
AU1 - Pitarresi, Giovanna
AU2 - Palumbo, Fabio Salvatore
AU3 - Fiorica, Calogero
AU4 - Bongiovì, Flavia
AU5 - Martorana, Annalisa
AU6 - Federico, Salvatore
AU7 - Chinnici, Cinzia Maria
AU8 - Giammona, Gaetano
AB - An alkyl functionalized gellan gum derivative is here used to produce hydrogels containing hydroxyapatite and tricalcium phosphate nanoparticles as injectable nanostructured scaffolds for bone regeneration. The amphiphilic nature of the polysaccharide derivative along with its thermotropic behavior and ionotropic crosslinking features make possible to produce injectable bone mimetic scaffolds that can be used to release viable cells and osteoinductive biomolecules. The influence of different nanoparticles concentration on the rheological and physicochemical properties of the injectable systems is studied. It is found that the presence of inorganic nanoparticles reinforces the 3D hydrated polymeric networks without influencing their injectability but improving the physicochemical properties of ionotropic crosslinked hydrogels produced with two different curing media. Preliminary cytocompatibility tests performed with murine preosteoblast cells revealed that gellan gum based hydrogels can safely encapsulate viable cells. Loading and release experiments for dexamethasone and stromal cell‐derived factor‐1 demonstrate the drug delivery features of the obtained injectable systems.
TI - Composite Hydrogels of Alkyl Functionalized Gellan Gum Derivative and Hydroxyapatite/Tricalcium Phosphate Nanoparticles as Injectable Scaffolds for bone Regeneration
JF - Macromolecular Bioscience
DO - 10.1002/mabi.202100290
DA - 2022-02-01
UR - https://www.deepdyve.com/lp/wiley/composite-hydrogels-of-alkyl-functionalized-gellan-gum-derivative-and-byH3xfBh5Z
VL - 22
IS - 2
DP - DeepDyve
ER -