TY - JOUR
AU - Bradford, Patricia A.
AB - Tigecycline has good broad-spectrum activity against many gram-positive and gram-negative pathogens with the notable exception of the Proteeae . A study was performed to identify the mechanism responsible for the reduced susceptibility to tigecycline in Proteus mirabilis . Two independent transposon insertion mutants of P. mirabilis that had 16-fold-increased susceptibility to tigecycline were mapped to the acrB gene homolog of the Escherichia coli AcrRAB efflux system. Wild-type levels of decreased susceptibility to tigecycline were restored to the insertion mutants by complementation with a clone containing a PCR-derived fragment from the parental wild-type acrRAB efflux gene cluster. The AcrAB transport system appears to be associated with the intrinsic reduced susceptibility to tigecycline in P. mirabilis .
TI - AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis
JO - Antimicrobial Agents and Chemotherapy
DO - 10.1128/AAC.47.2.665-669.2003
DA - 2003-02-01
UR - https://www.deepdyve.com/lp/american-society-for-microbiology/acrab-multidrug-efflux-pump-is-associated-with-reduced-levels-of-bspHDvDA0R
VL - 47
IS - 2
DP - DeepDyve
ER -