TY - JOUR
AU - Grunwald, David J.
AB - We have isolated and characterized the zebrafish ortholog of c‐ret, a gene essential for renal organogenesis and enteric nervous system development in mammals. During zebrafish embryogenesis c‐ret transcripts are expressed in a number of tissues including spinal motoneurons, pronephric ducts, cranial ganglia, pharyngeal arches, and the enteric nervous system. We have examined in detail the expression of c‐ret during the development of identified spinal primary motoneurons. c‐ret expression is regulated in a cell type‐specific manner among the three primary motoneurons. c‐ret is expressed at its highest levels in caudal primary (CaP) motoneurons and transcripts can be detected shortly before the expression of the CaP‐specific gene, islet2. We suggest that c‐ret may play a role in specifying CaP cell identity. c‐ret is expressed at low levels in the other primary motoneurons and also in a subset of secondary motoneurons, suggesting that it may also play a broader role in motoneuronal survival or maintenance. © 1997 John Wiley & Sons, Inc. J Neurobiol 33: 749–768, 1997
TI - Expression of c‐ret in the zebrafish embryo: Potential roles in motoneuronal development
JF - Developmental Neurobiology
DO - 10.1002/(SICI)1097-4695(19971120)33:6<749::AID-NEU4>3.0.CO;2-9
DA - 1998-08-20
UR - https://www.deepdyve.com/lp/wiley/expression-of-c-ret-in-the-zebrafish-embryo-potential-roles-in-bbSkp12iWm
SP - 749
EP - 768
VL - 33
IS - 6
DP - DeepDyve
ER -