TY - JOUR
AU1 - Gong, Huilin
AU2 - Gao, Ke
AU3 - Mao, Ping
AU4 - Ma, Shaohui
AU5 - Zhao, Dongli
AU6 - Bian, Yitong
AU7 - Liu, Rui
AU8 - Gao, Lu
AU9 - Duan, Qianqian
AU1 - Zhang, Qin
AU1 - Tan, Yuan
AU1 - Wang, Tuo
AB - To the Editor,Neurotrophic tyrosine receptor kinase (NTRK)‐rearranged spindle cell neoplasm is a rare soft tissue tumor defined by molecular features. The diagnosis of this tumor is difficult because of its nonspecific and highly variable morphology. Most NTRK‐rearranged spindle cell neoplasms present as superficial or deep tumors in the extremities or trunk. In this case, we report a 13‐year‐old boy who was found to have a lesion on the left parietal lobe. Initially, the clinical and radiological diagnosis was ganglioglioma. Histologic, immunohistochemical and molecular evaluation of the resection specimen demonstrated that it was a tropomyosin 3 gene (TPM3)‐NTRK1 spindle cell neoplasm. Only one pertinent case of fibroblastic spindle cell neoplasm with NTRK3 fusion arising in the temporal lobe has been documented. Therefore, our results add insight into the pathological features of this kind of tumor. Furthermore, with the rapid development of TRK‐targeted therapies, an accurate and timely diagnosis of these neoplasms has important therapeutic implications.A 13‐year‐old boy came to our hospital with sudden limb convulsions. There was no nausea, vomiting, bilateral limb weakness, or change in bilateral visual acuity. Magnetic resonance imaging (MRI) results showed a cystic‐solid mass in the left parietal cortex, with partly significant enhancement and extensive edema 
TI - A rare case of spindle cell neoplasm with NTRK‐fusion in central nervous system
JF - Pathology International
DO - 10.1111/pin.13260
DA - 2023-01-01
UR - https://www.deepdyve.com/lp/wiley/a-rare-case-of-spindle-cell-neoplasm-with-ntrk-fusion-in-central-bWWPz1Qdv0
SP - 52
EP - 54
VL - 73
IS - 1
DP - DeepDyve
ER -