TY - JOUR
AU - Kwon, Jungkee
AB - Abstract Proper wound management is an increasingly important clinical challenge and is a large and growing unmet need. Pressure ulcers, hard-to-heal wounds, and problematic surgical incisions are emerging with increasing frequency. At present, the wound-healing industry is experiencing a paradigm shift toward innovative treatments that exploit nanotechnology, biomaterials, and biologics. Here we determined the effectiveness of a radiation-processed hydrogel patch for the delivery of chestnut honey (CH) for the promotion of cutaneous wound healing in diabetic mice. CH is a natural compound that has antioxidant and bactericidal effects. Two full-thickness wounds were made on the dorsal side of diabetic (db/db) mice and the wounds were covered with hydrogel-incorporated CH. Time course observations revealed that mice treated with CH hydrogel showed accelerated wound closure and formation of granulated tissue, enhanced Ki-67 expression and early upregulated HO-1 proteins in the wound region compared with water hydrogel or non-treated mice. Taken together, these findings indicate that CH hydrogel can promote wound healing in diabetics with early HO-1 protein expression.
TI - Hydrogel incorporated with chestnut honey accelerates wound healing and promotes early HO-1 protein expression in diabetic (db/db) mice
JF - Tissue Engineering and Regenerative Medicine
DO - 10.1007/s13770-012-0036-2
DA - 2012-02-01
UR - https://www.deepdyve.com/lp/springer-journals/hydrogel-incorporated-with-chestnut-honey-accelerates-wound-healing-auu3YRJR01
SP - 36
EP - 42
VL - 9
IS - 1
DP - DeepDyve
ER -