TY - JOUR AU - Pontremoli, Roberto AB - BACKGROUNDBlood pressure (BP) and arterial stiffness are known cardiovascular risk factors in hemodialysis (HD) patients. This study examines the prognostic significance of 44-hour BP circadian rhythm and ambulatory arterial stiffness index (AASI) in this population.METHODSA total of 80 HD patients underwent 44-hour ambulatory BP monitoring (ABPM) with a TM-2430 monitor during a standard midweek interdialytic interval and followed up for 4.5 ± 1.7 years. The end point was all-cause mortality.RESULTSAbout 76% of participants were hypertensive (40% uncontrolled), 62% were nondippers, and 23% risers during the first interdialytic day, whereas 73% and 44% in the second day, respectively. During follow-up, 31 patients (40%) died. These showed higher pulse pressure (PP) and AASI44 and AASI of the second interdialytic period. The incidence of all-cause mortality was higher in HD patients with AASI44 > median, i.e. >0.54 (interquartile range = 14) (54% vs. 28%, χ 2 = 5.3, P = 0.021) when compared with those with lower AASI44. Second, but not first-day ABPM-derived parameters, namely nondipping (log-rank χ 2 = 6.10, P = 0.0134) or reverse dipping status (log-rank χ 2 = 5.32, P = 0.210) and arterial stiffness index (log-rank χ 2 = 6.61, P = 0.0101) were significantly related to greater mortality.CONCLUSIONSThese findings indicate a strong relationship between arterial stiffness and cardiovascular risk and support a wider use of 44-hour ABPM recording for risk stratification in HD patients. TI - Two-Day ABPM-Derived Indices and Mortality in Hemodialysis Patients JF - American Journal of Hypertension DO - 10.1093/ajh/hpz166 DA - 2020-02-22 UR - https://www.deepdyve.com/lp/oxford-university-press/two-day-abpm-derived-indices-and-mortality-in-hemodialysis-patients-akeg0PCUQ6 SP - 165 EP - 174 VL - 33 IS - 2 DP - DeepDyve ER -