TY - JOUR
AU - LEONARD, FRED
AB - Abstract THE N-alkyl-α-cyanoacrylate monomers are known for their ability to adhere to moist living tissues. Methyl-α-cyanoacrylate, in particular, has been used since 1960 by many investigators as a tissue adhesive for nonsuture of wounds, although this monomer was shown to be histotoxic.1-9 Work with the higher homologues of the N-alkyl-α-cyanoacrylates has indicated, however, that as one proceeds up the homologous series, histotoxicity decreases. It has been reported that the higher homologues wet, spread, and instantaneously polymerize on tissue substrates and are thereby more effective than the lower homologues in inducing hemostasis.10,11 In surgical applications, where it is required to bond two surfaces together, as in preparing an anastomosis or in adhering cut surfaces of an organ, instantaneous polymerization, however, is a disadvantage. In these instances, one requires sufficient working time to approximate the surfaces before adhesion is permitted to take place. During the course of an investigation References 1. Inou, T., et al: A New Adhesive for Vascular Surgery , J Int Coll Surg 44:3, 1965. 2. Awe, W.C.; Roberts, W.; and Braunwald, N.S.: Rapidly Polymerizing Adhesive as a Hemostatic Agent , Surgery 54:2, 1963. 3. Carton, C.A., et al: Experimental Studies in Surgery of Small Blood Vessels: II. Patching of Arteriotomy Using a Plastic Adhesive , J Neurosurg 18:2, 1961.Crossref 4. Healey, J.E., Jr., et al: Experiences With Plastic Adhesive in the Nonsuture Repair of Body Tissues , Amer J Surg 109:4, 1965. 5. Woodward, S.C., et al: Histotoxicity of Cyanoacrylate Tissue Adhesive in the Rat , Ann Surg 162: 113, 1965.Crossref 6. Pani, K.C.: Histotoxicity of Cyanoacrylate Plastics: Physiological Tissue Adhesive Monogram, University of Texas, to be published. 7. Sawyers, J.L., and Vasko, J.: Sealing Cut Lung Surfaces With Plastic Adhesive , J Thorac Cardiov Surg 46:4, 1963. 8. Wojnar, V.S., et al: Liver, Spleen, and Kidney Wounds , Arch Surg 89:237, 1964.Crossref 9. Yoho, A.V., et al: Experimental Evaluation of Tissue Adhesives in Urogenital Surgery , J Urol 92:1, 1964. 10. Collins, J.A., et al: Biological Substrates and Cure Rates of Cyanoacrylate Tissue Adhesives , Arch Surg 93:428, 1966.Crossref 11. Leonard, F.; Collins, J.A.; and Porter, H.J.: Interfacial Polymerization of N-Alkyl-α-Cyano-acrylate Homologs, Appl Polymer Sci, to be published.
TI - N-Alkyl-a-Cyanoacrylate Monomers in Surgery: Speed of Polymerization and Method of Their Application
JF - Archives of Surgery
DO - 10.1001/archsurg.1967.01330070155031
DA - 1967-01-01
UR - https://www.deepdyve.com/lp/american-medical-association/n-alkyl-a-cyanoacrylate-monomers-in-surgery-speed-of-polymerization-aikOZoWm08
SP - 153
EP - 156
VL - 94
IS - 1
DP - DeepDyve
ER -