TY - JOUR
AU - Fang, Ferric C.
AB - Specialized epithelia known as M cells overlying the lymphoid follicles of Peyer's patches are important in the mucosal immune system, but also provide a portal of entry for pathogens such as Salmonella typhimurium, Mycobacterium bovis, Shigella flexneri, Yersinia enterocolitica and reoviruses
1,2,3,4
. Penetration of intestinal M cells and epithelial cells by Salmonella typhimurium requires the invasion genes of Salmonella Pathogenicity Island 1 (SPI1)
3,5,6,7,8,9
. SPI1-deficient S. typhimurium strains gain access to the spleen following oral administration and cause lethal infection in mice
5
 without invading M cells
3,9
 or localizing in Peyer's patches
10
, which indicates that Salmonella uses an alternative strategy to disseminate from the gastrointestinal tract. Here we report that Salmonella is transported from the gastrointestinal tract to the bloodstream by CD18-expressing phagocytes, and that CD18-deficient mice are resistant to dissemination of Salmonella to the liver and spleen after oral administration. This CD18-dependent pathway of extraintestinal dissemination may be important for the development of systemic immunity to gastrointestinal pathogens, because oral challenge with SPI1-deficient S. typhimurium elicits a specific systemic IgG humoral immune response, despite an inability to stimulate production of specific mucosal IgA.
TI - Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes
JO - Nature
DO - 10.1038/44593
DA - 1999-10-21
UR - https://www.deepdyve.com/lp/springer-journals/extraintestinal-dissemination-of-salmonella-by-cd18-expressing-adh7400Lty
SP - 804
EP - 808
VL - 401
IS - 6755
DP - DeepDyve
ER -