TY - JOUR
AU1 - Idili, Andrea
AU2 - Porchetta, Alessandro
AU3 - Amodio, Alessia
AU4 - Vallée-Bélisle, Alexis
AU5 - Ricci, Francesco
AU6 - 
AB - Letter pubs.acs.org/NanoLett †,∥ †,∥ †,‡ ,§ ,† Andrea Idili, Alessandro Porchetta, Alessia Amodio, Alexis Vallee-Be ́ lisle, ́ * and Francesco Ricci* Dipartimento di Scienze e Tecnologie Chimiche, University of Rome, Tor Vergata, Rome, Italy PhD School of Nanotechnology, Department of Physics, University of Trieste, Trieste, Italy Laboratory of Biosensors and Nanomachines, Departement ́ de Chimie, Université de Montreal,́ Quebec, ́ Canada * Supporting Information ABSTRACT: By taking inspiration from nature, where self- organization of biomolecular species into complex systems is finely controlled through different stimuli, we propose here a rational approach by which the assembly and disassembly of DNA-based concatemers can be controlled through pH changes. To do so we used the hybridization chain reaction (HCR), a process that, upon the addition of an initiator strand, allows to create DNA-based concatemers in a controlled fashion. We re-engineered the functional units of HCR through the addition of pH-dependent clamp-like triplex-forming domains that can either inhibit or activate the polymerization reaction at different pHs. This allows to finely regulate the HCR-induced assembly and disassembly of DNA concatemers at either basic or acidic pHs in a reversible way. The strategies we present here appear particularly promising as novel tools to achieve 
TI - Controlling Hybridization Chain Reactions with pH
JF - Nano Letters
DO - 10.1021/acs.nanolett.5b02123
DA - 2015-07-22
UR - https://www.deepdyve.com/lp/unpaywall/controlling-hybridization-chain-reactions-with-ph-acvKHyebTg
DP - DeepDyve
ER -