TY - JOUR
AU - Victor, Gary H.
AB - A monoclonal antibody directed against murine tumor necrosis factor-α (TNF) was studied in a neutropenic rat model to determine its efficacy in protecting animals from lethal infection with Pseudomonas aeruginosa. Anti-TNF monoclonal antibody at a dose of 20 mg/kg given intravenously at 0 and 120 h resulted in a 53% survival rate (8/15) compared with no survival in control animals (0/15) (P < .(05). The combination of anti-TNF monoclonal antibody and oral ciprofloxacin at a suboptimal dose of 2.5 mg/kg/day resulted in a 100% survival rate in neutropenic animals (16/16), while ciprofloxacin alone produced only, a 67% survival rate (10/15) during the 7-day period of neutropenia (P < .05). Thus anti-TNF monoclonal antibody alone or in addition to antimicrobial agents improved survival in neutropenic animals after infection with P. oeruginosa.
TI - Efficacy of a Monoclonal Antibody Directed against Tumor Necrosis Factor in Protecting Neutropenic Rats from Lethal Infection with Pseudomonas aeruginosa
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/161.6.1148
DA - 1990-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/efficacy-of-a-monoclonal-antibody-directed-against-tumor-necrosis-aVcpXwYN9g
SP - 1148
EP - 1152
VL - 161
IS - 6
DP - DeepDyve
ER -