TY - JOUR AU1 - Denis, F. AU2 - Mounier, M. AU3 - Hessel, L. AU4 - Michel, J. P. AU5 - Gualde, N. AU6 - Dubois, F. AU7 - Barin, F. AU8 - Goudeau, A. AB - THE JOURNAL OF INFECTIOUS DISEASES • VOL. 149, NO.6· JUNE 1984 © 1984 by The University of Chicago. All rights reserved. 0022-1899/84/4906-0026$01.00 immune response to hepatitis-B vaccine; overall, only 32 Legend. Antibody to hepatitis-B surface antigen (anti­ HBs) seroconversion in various age groups after three in­ (45.7%) of 70 patients developed anti-HBs. The sero­ jections of vaccine. conversion rate decreased with advancing age (P = .05 by Spearman rank one-tailed test). These results contrast No. seroconverting/total no. tested Age group with the 96% seroconversion rate observed when the (years) Men Women Total (070) same vaccine was administered to a younger adult population [3]. 417 5/6 9/13 (69.2) 61-70 An age-dependent anti-HBs response to hepatitis-B 71-80 4/6 3/10 7/16 (43.7) 81-90 4/6 11/32 15/38 (39.5) vaccine in patients undergoing periodic hemodialysis 91-96 1/3 1/3 (33.3) has been reported [3]. For uninfected patients with a 20/51 32170 (45.7) Total 12/19 positive antibody response, the mean titer was 1,200,000 IU/ml in the younger population (mean age, 30 years), Summary compared with a mean titer of 172,000 IU/ml (obtained one month following the third injection of the vaccine) Elderly patients living in institutions ("chronic-care in our study of patients more than 60 years TI - Hepatitis-B Vaccination in the Elderly JF - The Journal of Infectious Diseases DO - 10.1093/infdis/149.6.1019 DA - 1984-06-01 UR - https://www.deepdyve.com/lp/oxford-university-press/hepatitis-b-vaccination-in-the-elderly-a9vrxHlCE1 SP - 1019 EP - 1019 VL - 149 IS - 6 DP - DeepDyve ER -