TY - JOUR
AU1 - Hu, A.-P.
AU2 - Du, J.-M.
AU3 - Li, J.-Y.
AU4 - Liu, J.-W.
AB - © Birkhäuser Verlag, Basel, 2008 Infl amm. res. 57 (2008) 163–170 1023-3830/08/040163-8 Infl ammation Research DOI 10.1007/s00011-007-7193-0 Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes 1 2 2 1 A.-P. Hu , J.-M. Du , J.-Y. Li and J.-W. Liu State Key Laboratory of Bioreactor Engineering & School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China, Fax: ++86 21 64252044, e-mail: liujian@ecust.edu.cn Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China Received 16 October 2007; accepted by G. Wallace 26 November 2007 Published Online First 20 March 2008 Abstract. Objective and design: Oridonin is an ent-kaurene Introduction diterpenoid extracted from Isodon Serra, and we have previ- ously demonstrated its immunosuppressive effect. Our goal Regulatory T cells (Tregs) are a subset of T lymphocytes that + + was to study how Oridonin impacts CD4 /CD25 regulatory play a core role in immunological suppression and the termi- T cells (Tregs) and Th1/Th2 balance, as well as its effect on nation of immune responses, and defi ciency or dysfunction the anti-infl ammatory target HO-1. of these cells may lead to autoimmunity or aggravated patho- 
TI - Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes
JF - Inflammation Research
DO - 10.1007/s00011-007-7193-0
DA - 2008-03-20
UR - https://www.deepdyve.com/lp/springer-journals/oridonin-promotes-cd4-cd25-treg-differentiation-modulates-th1-th2-a8kAZVg0Sp
SP - 163
EP - 170
VL - 57
IS - 4
DP - DeepDyve
ER -