TY - JOUR
AU1 - Li, Yayong
AU2 - Sun, Kaiyue
AU3 - Chen, Shenna
AU4 - Zhao, Juan
AU5 - Lei, Yuhua
AU6 - Geng, Lina
AB - Nano-resveratrol liposome (RES-LIP) was prepared by the thin film rotary-evaporated method combined with ultrasonication and characterized by transmission electron microscopy (TEM), zeta potential, dynamic light scattering (DLS), and Fourier-transform infrared (FT-IR). The physicochemical stability, in vitro release, antioxidant activity, and cytotoxicity of RES-LIP were studied. Data showed that RES-LIP was a spherical vesicle with a diameter of less than 100 nm, the zeta potential was − 60 mV and the encapsulation efficiency was 86.78%. The physicochemical stability of RES-LIP was determined by Ea, ΔG, ΔH, and ΔS, which suggested that the process of RES-LIP degradation was spontaneous and endothermic. The in vitro release of RES-LIP was pH-dependent, belonged to the Weibull model, and was non-Fick diffusion. The antioxidant activity of RES-LIP was stronger than free resveratrol. The MTT assay and flow cytometry results suggested that resveratrol decreased cytotoxicity after being encapsulated by liposome. The prepared RES-LIP had high encapsulation efficiency, was sustained-release, had low cytotoxicity, was pH-targeted, and had potential usage in food and medicine fields.
TI - Nano-Resveratrol Liposome: Physicochemical Stability, In Vitro Release, and Cytotoxicity
JF - Applied Biochemistry and Biotechnology
DO - 10.1007/s12010-023-04344-w
DA - 2023-10-01
UR - https://www.deepdyve.com/lp/springer-journals/nano-resveratrol-liposome-physicochemical-stability-in-vitro-release-a36ZHnqKC0
SP - 5950
EP - 5965
VL - 195
IS - 10
DP - DeepDyve
ER -